Results 61 to 70 of about 4,064 (126)

Genetic Dissection of Femoral and Tibial Microarchitecture

JBMR Plus, 2019
Our understanding of the genetic control of bone strength has relied mainly on estimates of bone mineral density. Here we have mapped genetic factors that influence femoral and tibial microarchitecture using high‐resolution x‐ray computed tomography (8 ...
Lu Lu, Jinsong Huang, Fuyi Xu, Zhousheng Xiao, Jing Wang, Bing Zhang, Nicolae Valentin David, Danny Arends, Weikuan Gu, Cheryl Ackert‐Bicknell, Olivia L Sabik, Charles R Farber, Leigh Darryl Quarles, Robert W Williams   +13 more
doaj   +1 more source

Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells

Stem Cell Research & Therapy, 2018
Background Osteoarthritis (OA) is a widespread arthritic disease and a primary cause of disability. Increasing evidence suggests that inflammation has a pivotal part in its pathogenesis.
Bo Gao, Wenjie Gao, Zizhao Wu, Taifeng Zhou, Xianjian Qiu, Xudong Wang, Chengjie Lian, Yan Peng, Anjing Liang, Jincheng Qiu, Yuanxin Zhu, Caixia Xu, Yibing Li, Peiqiang Su, Dongsheng Huang   +14 more
doaj   +1 more source

Effect of dietary Eucommia ulmoides oliver polysaccharide on immune function and meat quality of Songliao Black Pigs

Scientific Reports
Eucommia ulmoides is a traditional Chinese herbal medicine, with pharmacological effects such as lowering blood pressure and enhancing immune function. The effects of dietary Eucommia ulmoides polysaccharide (EUP) on immune function and meat quality were
Yang Liang, Zeyu Tang, Hao Wang, Meng Liu, Fanglin Zhao, Longsheng Wang, Yinbiao Meng, Lijun Jia   +7 more
doaj   +1 more source

A splice variant of ADAMTS4 is expressed as a protein in human osteoarthritis synovium and cleaves aggrecan at the interglobular domain [PDF]

Osteoarthritis and Cartilage, 2014
Wainwright, S.D., Bondeson, J., Caterson, B., Hughes, C.E.   +3 more
openaire   +1 more source

The novel HSP90 monoclonal antibody 9B8 ameliorates articular cartilage degeneration by inhibiting glycolysis via the HIF-1 signaling pathway

Heliyon
Osteoarthritis (OA) is a prevalent chronic degenerative disease that affects the bones and joints, particularly in middle-aged and elderly individuals. It is characterized by progressive joint pain, swelling, stiffness, and deformity.
Shunan Yu, Xiong Shu, Xinyu Wang, Yueyang Sheng, Shan Li, Ying Wang, Yanzhuo Zhang, Jiangfeng Tao, Xu Jiang, Chengai Wu   +9 more
doaj   +1 more source

Identification of a basement membrane-related gene signature for predicting prognosis, immune infiltration, and drug sensitivity in colorectal cancer

Frontiers in Oncology
BackgroundColorectal cancer (CRC) is the most common malignancy affecting the gastrointestinal tract. Extensive research indicates that basement membranes (BMs) may play a crucial role in the initiation and progression of the disease.MethodsData on the ...
Xiang Shengxiao, Sun Xinxin, Zhu Yunxiang, Tang Zhijie, Tang Xiaofei   +4 more
doaj   +1 more source

Effects of Oligomeric Proanthocyanidins on Cadmium-Induced Extracellular Matrix Damage via Inhibiting the ERK1/2 Signaling Pathway in Chicken Chondrocytes

Veterinary Sciences
Cadmium (Cd) is a toxic, non-essential metal that primarily enters animal bodies through the digestive and respiratory systems, leading to damage to multiple organs and tissues.
Jianhong Gu, Dan Liu, Anqing Gong, Xinrui Zhao, Jiatao Zhou, Panting Wang, Han Xia, Ruilong Song, Yonggang Ma, Hui Zou, Muhammad Azhar Memon, Yan Yuan, Xuezhong Liu, Jianchun Bian, Zongping Liu, Xishuai Tong   +15 more
doaj   +1 more source

Persistence of alveolar fibroblast-derived ADAMTS4+ cells in a preclinical model of delayed pulmonary fibrosis resolution. [PDF]

Nat Commun
Zabihi M, Khadim A, Lingampally A, Vazquez-Armendariz AI, Hadzic S, Panagiotidis GD, Kalina D, Halweg J, Procida-Kowalski T, Bartkuhn M, Chu X, Koepke J, Samakovlis C, Boehm M, Weissmann N, Günther A, Seeger W, Braubach P, Herold S, Wygrecka M, Bellusci S, El Agha E.   +21 more
europepmc   +1 more source

Adamts4 coordinates the transcriptomic profile of primary rat costal chondrocytes. [PDF]

Stem Cells Transl Med
Wei Z, Chen Y, Kou W, Zhang Y, Sha W, Guo R, Lei Y, Zhang N, Shi Y, Wang Z.   +9 more
europepmc   +1 more source

Synovial Fluid Proteomic Biomarkers in Knee Osteoarthritis: A Systematic Review and Gene Ontology Analysis. [PDF]

Cartilage
Parrotta EI, Benedetto GL, Cuda G, Covello R, Longo UG, Carnevale A, Galasso O, Gasparini G, Mercurio M.   +8 more
europepmc   +1 more source