Recent Advances Regarding the Therapeutic Potential of Adapalene
Pharmaceuticals, 2020 Adapalene (ADP) is a representative of the third retinoids generation and successfully used in first-line acne treatment. ADP binds to retinoic acid nuclear receptors.
Nicoleta Todoran +2 more
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A Mechanistic Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach Informed by In Vitro and Clinical Studies for Topical Administration of Adapalene Gels [PDF]
PharmaceuticsBackground/Objectives: Adapalene is a synthetic retinoid used as a treatment for acne vulgaris. In this study, we attempted to evaluate the dermal pharmacokinetics of adapalene utilizing experimental and in silico tools.
Namrata S. Matharoo +8 more
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Development of Adapalene Loaded Liposome Based Gel for Acne
Gels, 2023 Retinoids are considered the mainstay treatment for moderate to severe acne. Adapalene, a third-generation retinoid, has physiochemical properties which hinder the effective delivery of the drug to the skin.
Naveed Ahmed +2 more
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Adapalene, an RAR agonist, exerts anti-inflammatory effects by regulating macrophage polarization through RAR $$\upbeta$$ -mediated signaling pathways [PDF]
Scientific ReportsRetinoic acid receptor (RAR) is a nuclear receptor that plays a critical role in regulating cellular proliferation and differentiation through transcriptional control.
Na Hyun Lee +4 more
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Treatments for molluscum contagiosum: A systematic review. [PDF]
J Dtsch Dermatol GesSummary Molluscum contagiosum (MC) is a viral skin infection that poses significant physical and psychosocial burdens, particularly in pediatric and immunocompromised populations. Despite the availability of various treatment options, comparative efficacy and safety data remain limited.
Wang OJE +3 more
europepmc +2 more sources
Eco-friendly, stability-indicating micellar HPLC-UV method for simultaneous determination of clindamycin phosphate and adapalene in gel formulations [PDF]
BMC ChemistryA rapid, accurate, sensitive, and eco-friendly micellar liquid chromatography method has been successfully developed and validated for the simultaneous determination of clindamycin and adapalene in their bulk forms and combined dosage gel formulations ...
Bassant Samy +3 more
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Clascoterone Stability When Combined with Topical Acne Medications In Vitro [PDF]
Dermatology and TherapyIntroduction Multimodal topical therapy is recommended by the American Academy of Dermatology for the treatment of acne vulgaris. However, no data are available regarding stability of clascoterone cream 1% when combined with other topical acne ...
Zoe D. Draelos +3 more
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Efficacy and Safety of Melaleuca alternifolia (Tea Tree) Oil for Acne-A Systematic Review and Meta-Analysis. [PDF]
Phytother ResABSTRACT Acne vulgaris is a common chronic inflammatory skin disorder that begins in adolescents and often persists into adulthood, with substantial psychosocial impact. Tea tree oil (TTO) has been explored as a topical treatment for acne, but clinical evidence for its efficacy and safety remain limited and inconsistent. This systematic review and meta‐
Ye Y, Lim JJ, Huang Z, Chew FT.
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Comparative Study between Topical Metformin 30% Cream and Topical Adapalene 0.1 % Cream in The Treatment of Acanthosis Nigricans [Clinicodermoscopic Study] [PDF]
International Journal of Medical Arts, 2023 Background: Acanthosis nigricans [AN] is a common cutaneous disorder with multiple etiologies. For cosmetic purposes, dermatologists usually recommend topical keratolytics, laser treatments, or chemical peels.
Sabrean Elkhodary +2 more
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Frontiers in Oncology, 2022 Doxorubicin is a commonly used chemotherapeutic agent to treat several malignancies, including aggressive tumors like triple-negative breast cancer. It has a limited therapeutic index owing to its extreme toxicity and the emergence of drug resistance. As
Umar Mehraj +5 more
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