Results 61 to 70 of about 2,255 (154)

Metabolic Dysregulation of FC3 Fibrochondrocytes via MDH2 Promotes Intervertebral Disc Degeneration

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of chronic low back pain, yet the specific cell subpopulations and metabolic mechanisms driving its progression remain incompletely understood. We performed an integrative analysis of single‐cell RNA sequencing (scRNA‐seq) and transcriptomic sequencing using public datasets (GSE230809 ...
Xingye Li, Jinbao Tian, Zhongning Xu, Yan An, Jincheng Guo, Da He   +5 more
wiley   +1 more source

Adapalene 0.1% lotion in the treatment of acne vulgaris: results from two placebo-controlled, multicenter, randomized double-blind, clinical studies.

, 2010
BACKGROUND: Acne vulgaris is a common chronic skin disease affecting roughly 15 percent of the general population and up to 85 percent of adolescents and young adults.
Jarratt, Michael, Manna, Vasant, Eichenfield, Lawrence F, Liu, Yin, Schleicher, Stephen, MD, Schlessinger, Joel, Adapalene Lotion Study Group, Hwa, Joyce, Graeber, Michael, Kempers, Steven   +9 more
core  

Comparison of efficacy and tolerability of tretinoin gel 0.05% with adapalene gel 0.1% in treating mild to moderate acne vulgaris

Fiyz̤, 2018
Background: Acne vulgaris is an inflammatory skin disease. Topical retinoids with significant anti-inflammatory properties are used for treatment of acne. The common side effect of topical retinoids is local irritation.
Akram Ansar , Pedram Alirezaei , Sajjad Daneshyar, Bita Sharafi , Saadat Torabian   +4 more
doaj  

Adapalene‐Associated Cutaneous Adverse Events: A Disproportionality Analysis of the FAERS Database

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
Zhongping Cao, Chenyu Zhao
wiley   +1 more source

Update of the EuroGuiDerm evidence‐based guideline for the treatment of acne—Short version

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 7, Page 1162-1172, July 2026.
The 2025 EuroGuiDerm guideline update provides evidence‐based recommendations for acne management, addressing systemic antibiotics, systemic isotretinoin, hormonal therapies including spironolactone and contraceptives, and new topical agents. Key considerations include treatment duration, safety, pregnancy‐specific guidance and minimizing antibiotic ...
Alexander Nast, Bassel H. Al Wattar, Marie Beylot Barry, Holger Brüggemann, Zrinka Bukvić Mokos, Dawn M. Caruana, Klaus Degitz, Clio Dessinioti, Brigitte Dréno, Rieke J. B. Driessen, Harald Gollnick, Merete Hædersdal, Alexander Katoulis, Severin Läuchli, Julien Lambert, Alison M. Layton, Giuseppe Micali, Falk R. Ochsendorf, Thozhukat Sathyapalan, Katarina Zak Stangeland, Simon Francis Thomsen, Daniel Töröcsik, Antonia Pennitz   +22 more
wiley   +1 more source

Efficacy and Tolerability of Topical Trifarotene in Managing Acne Vulgaris Among Malaysians: A Single Arm, Open Label, Observational Study

Journal of Cosmetic Dermatology, Volume 25, Issue 7, July 2026.
ABSTRACT Background Trifarotene is a new fourth‐generation topical retinoid that selectively binds to RAR‐γ receptors. However, the efficacy and safety data of trifarotene on Asians are lacking. Thus, we evaluated its real‐world efficacy and tolerability among Malaysians.
Jun Hui Goh, Tatt Quan Tan, Wen Chung Ho, Chi Fai Lee, Meroshini Sundaran, JiaXu An, Kang Nien How   +6 more
wiley   +1 more source

Epidemiology and Treatment Challenges of Acne, With Insights Into the Role of Dermocosmetics: An Expert Consensus From India—A Modified Delphi Method

Journal of Cosmetic Dermatology, Volume 25, Issue 7, July 2026.
ABSTRACT Background Acne vulgaris is a common skin condition that typically begins in adolescence but can often persist in adulthood, contributing to significant physical and psychosocial burden. Despite the availability of multiple treatment options, challenges such as poor adherence, treatment‐related side effects, and post‐inflammatory ...
Mukta Sachdev, Nina Madnani, Malavika Kohli, Koushik Lahiri, Anurag Tiwari, Kalpana Sarangi, Rajat Kandhari, Rajetha Damisetty, Ramesh Bhat, Delphine Kerob, Shefali Trasi‐Nerurkar   +10 more
wiley   +1 more source

Modern Outlooks on Pathogenesis, Clinical Picture, Diagnosis and Management of Acne Vulgaris in Children and Adolescents

Вопросы современной педиатрии, 2020
В статье представлены современные данные о патогенезе вульгарных акне (ВА), особенностях клинической картины, диагностике и терапевтической тактике у детей и подростков.
Elena R. Araviiskaia, Nikolay N. Murashkin, Leyla S. Namazova-Baranova, Roman A. Ivanov   +3 more
doaj   +1 more source

Anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% and adapalene 0.1% in rats

, 2005
In this study, the anti-inflammatory effects of tretinoin (all-trans-retinoic acid) 0.1% cream and adapalene 0.1% gel were compared in rats to determine whether there was a difference between these agents.
Metin, A, Calka, O, Ozbek, H, Akdeniz, N
core   +1 more source

Adapalene-loaded poly(ε-caprolactone) microparticles: Physicochemical characterization and in vitro penetration by photoacoustic spectroscopy

, 2019
Adapalene (ADAP) is an important drug widely used in the topical treatment of acne. It is a third-generation retinoid and provides keratolytic, anti-inflammatory, and antiseborrhoic action. However, some topical adverse effects such as erythema, dryness,
Jessica Mendes Nadal (6494849), João Ricardo Roik (6494870), Guilherme Dos Anjos Camargo, João Ricardo Roik, Andressa Novatski (6494855), Amanda Lyra, Amanda Lyra (6494867), Daniele Toniolo Dias (6494861), Josiane Padilha de Paula (6494873), Fernanda Malaquias Barboza, Josiane Padilha de Paula, Guilherme dos Anjos Camargo (6494852), Fernanda Malaquias Barboza (6494864), Andressa Novatski, William Roger Macenhan, Aloisi Somer, Aloisi Somer (6494876), Paulo Vitor Farago, Jessica Mendes Nadal, William Roger Macenhan (6494858), Paulo Vitor Farago (6131732), Daniele Toniolo Dias   +21 more
core   +1 more source