Results 111 to 120 of about 1,695,526 (286)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Cooperation Regulation of Antioxidative System and Hormone Contents on Physiological Responses of Wedelia trilobata and Wedelia chinensis under Simulated Drought Environment

Plants
Drought-induced metabolic dysregulation significantly enhances the production of reactive oxygen species (ROS), which, in turn, exerts a substantial influence on the oxidation–reduction regulatory status of cells.
Ping Huang, Zhiwei Xu, Weijie He, Hong Yang, Bin Li, Wendian Ding, Yuze Lei, Adeel Abbas, Rashida Hameed, Congyan Wang, Jianfan Sun, Daolin Du   +11 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

What futures for Eastern Africa highlands under threat of climate change? Exploring alternative pathways in two traditional farming communities through participatory scenarios.[ID354] [PDF]

, 2019
Climate change is amongst the greatest future challenges and threats to food security for millions of people across the African continent. Tackling climate change effects and designing transformative pathways for adaptation requires accounting for ...
Capitani, Claudia, Garedew, Weyessa, Hailu, Binyam Tesfau, Heiskanen, Janne, Hurskainen, Pekka, Johansson, Tino, Marchant, Robert, Mitiku, Amsalu, Pinard, Fabrice, Platts, Philip J., Siljander, Mika, Yadessa, Gezahegn   +11 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Climate impacts and adaptation strategies for coastal erosion, aquaculture, and tourism along the Adriatic side of Apulia region

Frontiers in Climate
This study addresses the imperative need for adaptation strategies to climate impacts in coastal areas, particularly vulnerable to climate change effects.
Giuseppe Parete, Maria Francesca Bruno, Pietro Calabrese, Roberto Carlucci, Miriam Chiarulli, Gianfranco D'Onghia, Annunziata Fiore, Umberto Fratino, Caterina Longo, Francesco Longo, Serena Scorrano, Francesco Gentile   +11 more
doaj   +1 more source

Marine Law Symposium at RWU Law to Focus on Legal Strategies for Climate Adaptation [PDF]

, 2018
Nov. 16 event will be part of RWU’s yearlong series, “Ocean State/State of the Ocean: The Challenge of Sea-Level Rise Over the Coming Century”
Fitzpatrick, Edward
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source