Results 101 to 110 of about 913,974 (268)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
“Social Relations between the Sexes in Athena Farrokhzad’s Morals According to Medea”
Litera: Dil, Edebiyat ve Kültür Araştırmaları DergisiThis paper explores how patriarchal power relations construct the idea of “nature” in Athena Farrokhzad’s Morals According to Medea (Moral enligt Medea, 2022), an adaptation of Euripides’ classic play Medea (431 BCE).
Pelin Dogan Özger
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
NalansMelville’s Bartleby, the Scrivener: A Story of Wall Street (1853) is a short story that offers a multiplicity of readings not only because of the complexity of its main characters but also because of Melville’s imaginary of Wall Street.
Daniela Jose Cid Opazo
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
transLogos: Translation Studies JournalComparatively analyzing films through the lenses of translation and adaptation studies may prove to be functional in understanding how texts evolve across different mediums, languages, and cultures.
Bora Arga
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Film Adaptations of Contemporary Polish Literature. An Attempt to Characterize the Phenomenon
Załącznik KulturoznawczyThe article is devoted to the latest phenomenon of adapting contemporary Polish literature into film. As the author assumes, starting from Polish-Russian War (2009), Polish filmmakers have been increasingly interested in adapting narratively and ...
Robert Birkholc
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source