Results 81 to 90 of about 913,974 (268)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Філологічні студіїThe emergence of digital platforms of games marketed as “Lovecraftian” raises a question that has not yet been systematically addressed in academic discourse: how does a game that truly immerses the player in the world of Lovecraftian horror differ from ...
Andrii Isakov
doaj +1 more source
Challenging Adaptation Studies: A Review of Comics and Adaptation
The Comics Grid: Journal of Comics Scholarship, 2019 Comics and Adaptation, edited by Benoît Mitaine, David Roche and Isabelle Schmitt-Pitiot, translated by Aarnoud Rommens and David Roche, University Press of Mississippi; 238 pages, 2018, ISBN 978-1-4968-0337-5 This review discusses the contents of the edited collection Comics and Adaptation (edited by Benoît Mitaine, David Roche and Isabelle Schmitt ...
openaire +3 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Adolescent internet adaptability: A scale adaptation study
ODÜ Sosyal Bilimler Araştırmaları Dergisi (ODÜSOBİAD)In today's rapidly digitalising world, adolescents' intensive use of the Internet presents both developmental opportunities and a range of psychosocial risks. Internet addiction, cyberbullying, and other challenges encountered in digital environments can adversely affect adolescents' psychological resilience and social adjustment.
Emrah Akman +2 more
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source