Results 121 to 130 of about 648,356 (307)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Application of Improved Sage-Husa Algorithm in SINS/GPS Integrated Navigation

Journal of Harbin University of Science and Technology
To address the issues of low filtering accuracy and poor reliability encountered when employing the Sage-Husa adaptive filtering algorithm in combined navigation systems, an improved Sage-Husa adaptive filtering algorithm is proposed.
WEN Sheng, LIU Caiyun, LUAN Tiantian, SUN Mingxiao   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Bounded Ability Estimation for Computerized Adaptive Testing [PDF]

Advances in Neural Information Processing Systems 36, 2023
Zhuang, Yan, Liu, Qi, Zhao, GuanHao, Huang, Zhenya, Huang, Weizhe, Pardos, Zachary A, Chen, Enhong, Wu, Jinze, Li, Xin   +8 more
openaire   +2 more sources

Cleaning ability of rotary NiTi systems with different kinematics

Bulletin of the National Research Centre, 2019
Background The aim of this study was to compare the cleaning ability of rotary NiTi systems with different kinematics: ProTaper Next (PTN) (continuous rotation motion), WaveOne Gold (WOG) (reciprocating motion), and Twisted File Adaptive (TFA) (adaptive ...
Amira Galal Ismail, Mohamed Mokhtar Nagy, Manar Galal   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Coordinated Adaptation for Adaptive Context-aware Applications [PDF]

The ability to adapt to change is critical to both mobile and context-aware applications. This thesis argues that providing suf?cient support for adaptive context-aware applications requires support for coordinated adaptation.
Efstratiou, Christos
core  

DEVELOPMENT OF COLLABORATIVE PROBLEM SOLVING-BASED LEARNING TOOLS TO IMPROVE MATHEMATICAL ADAPTIVE REASONING SKILLS

Aksioma: Jurnal Program Studi Pendidikan Matematika
Students' ability to solve mathematical adaptive reasoning problems is still relatively low. As a result, students have difficulty in solving mathematical adaptive reasoning problems.
Nunu Nurhayati, Yaya Sukjaya Kusumah, Dadang Juandi   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source