Results 131 to 140 of about 648,356 (307)
A Model-Driven Approach for Validating Safe Adaptive Behaviors
, 2016 Conference of 19th Euromicro Conference on Digital System Design, DSD 2016 ; Conference Date: 31 August 2016 Through 2 September 2016; Conference Code:124486International audienceAdaptive embedded software systems have the ability to adapt themselves in ...
Reda Nouacer +5 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Towards adaptable and adaptive policy-free middleware
, 2011 Submitted to Dependable and Adaptive Distributed Systems Track, ACM SAC 2007We believe that to fully support adaptive distributed applications, middleware must itself be adaptable, adaptive and policy-free.
Macdonald, Angus +4 more
core
Developing adaptive digital book (ADB) in enhancing students’ numeracy literacy ability
InfinityNumeracy literacy is essential for students to solve interrelated problems across various subjects. However, students' numeracy literacy skills remain low, necessitating innovative learning resources.
Yerizon Yerizon +5 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
FORMS : Unifying Reference Model for Formal Specification of Distributed Self-adaptive Systems
, 2012 The challenges of pervasive and mobile computing environments, which are highly dynamic and unpredictable, have motivated the development of self-adaptive software systems. Although noteworthy successes have been achieved on many fronts, the construction
Weyns, Danny +5 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
08031 Software Engineering for Self-Adaptive Systems: A Research Road Map
, 2008 Software's ability to adapt at run-time to changing user needs, system intrusions or faults, changing operational en- vironment, and resource variability has been proposed as a means to cope with the complexity of today's software- intensive systems.
Dustdar, Schahram +3 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source