Results 71 to 80 of about 1,241,988 (301)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Assessing leverage points for strengthening adaptive capacity in a Global South food system: A psychometric approach

open access: yesClimate Risk Management
Despite the burgeoning literature on adaptive capacity, there is a lack of psychometric approaches for assessing the determinants of adaptive capacity, particularly in food systems in the Global South.
Linda M. Rosengren   +3 more
doaj   +1 more source

Application of adaptive antenna technology to third generation radio architectures [PDF]

open access: yes, 1994
Work at Bristol has considered the application of adaptive antenna technology to a mixed cell architecture employing DS-CDMA as the air interface. In the scenario considered, both the umbrella cells and the underlying micro cells operate within the same ...
Beach, MA, Swales, SC, Tsoulos, GV
core   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Crafting Adaptive Capacity

open access: yes, 2017
Institutional bricolage, which explains how institutions are actively crafted across different degrees of formality, and urban adaptation have been studied separately in the past. Linking critical institutionalism and adaptive capacity research, this article describes how institutional bricolage shapes the distribution of adaptive capacity in ...
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Climate smart strategies to strengthened coffee farmers adaptive capacity to climate change. [P74] [PDF]

open access: yes, 2015
In the last 30 years Kenya's national coffee production decreased by about 70%. In some areas like Muranga County, the decline was up to fivefold and coffee is now replaced by food crops in lower altitudes due to erratic rainfall and increased ...
Asayehegn, Kinfe   +4 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Innovation Lab For Museums: Case Studies in Innovation and Adaptive Capacity [PDF]

open access: yes, 2015
This case study on Latino New South follows the journey and partnerships of three cultural institutions -- the Levine Museum of the New South (Charlotte, NC), the Atlanta History Center (Atlanta, GA), and the Birmingham Civil Rights Institute (Birmingham,
Jamie Gamble
core  

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