Results 61 to 70 of about 646,279 (275)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Effect of Family-Based Psychological and Educational Interventions on Improving Adaptive Behaviors in Students with Intellectual Impairment [PDF]

Ravānshināsī-i Afrād-i Istis̠nāyī, 2014
The present study aimed to investigate effects of family-based psychological and educational interventions on improving adaptive behaviors of school students with mental impairment. It followed a semi-experimental research design.
Ahmad Yarmohammadian
doaj  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Low-Similarity Client Sampling for Decentralized Federated Learning

IEEE Access
Federated Learning (FL) often encounters challenges from statistical heterogeneity caused by non-identical client data distributions. A common approach to mitigate this issue is to cluster clients with similar data and train within each cluster, which ...
Yunseok Kang, Jaeyoung Song
doaj   +1 more source

Investigating The Mediating Role of Cognitive Emotion Regulation Strategies in The Relationship Between Meta-cognitive Beliefs and Learning Anxiety [PDF]

Iranian Evolutionary Educational Psychology Journal, 2021
The aim of this study was to investigate the mediating role of adaptive and maladaptive strategies of cognitive emotion regulation in the relationship between metacognitive beliefs and learning anxiety. The present study was a correlational method.
Mahtab Yousefi, Majid Barzegar, Maryam Kouroshnia, Mohammad Khayyer   +3 more
doaj  

Adaptive Cluster Sampling for Forest Inventories

Forest Science, 1993
Abstract Adaptive cluster sampling is shown to be a viable alternative for sampling forests when there are rare characteristics of the forest trees which are of interest and occur on clustered trees. The ideas of recent work in Thompson (1990) have been extended to the case in which the initial sample is selected with unequal ...
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

ADAPTIVE CLUSTER SAMPLING USING AUXILIARY VARIABLE [PDF]

Journal of Mathematics and Statistics, 2013
في هذه الدراسة، ندرس مقدري متوسط السكان في أخذ العينات العنقودية التكيفية باستخدام معلومات المتغير المساعد. المقدرون في هذه الدراسة هم مقدر النسبة الكلاسيكية، ومقدر النسبة باستخدام معامل التباين السكاني ومعامل تقشر المتغير المساعد، ومقدر الانحدار، ومقدر الفرق. أظهرت المحاكاة أن مقدر الفرق كان لديه أصغر خطأ متوسط مربع مقدر عند مقارنته بمقدر النسبة ومقدر
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source