Results 81 to 90 of about 646,279 (275)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Energy-Efficient Data Collection Scheme for Environmental Quality Management in Buildings

IEEE Access, 2018
How to efficiently collect sensory data for supporting energy-efficient operation of buildings has become a great challenge, especially for large-scale networks in buildings.
Siguang Chen, Jiasheng Zhou, Xiaoyao Zheng, Xiukai Ruan   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Accounting for physical barriers in insect pest modeling: A spatially explicit simulation-based approach

Ecological Informatics
Understanding pest dynamics beyond greenhouse boundaries is critical for anticipating outbreaks and guiding sustainable management. Despite the central role of insect pest ecology in Integrated Pest Management, landscape-scale research on external ...
Juan M. Requena-Mullor, Estefanía Rodríguez, Mónica González, Antonio J. Castro, Enrica Garau, Irene Pérez-Ramírez, Álvaro Peláez-Pérez, Pablo Barranco   +7 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Impact of Training Program to the Improvement of Teaching Competency in Adaptive Physical Education

Indonesian Journal of Disability Studies, 2019
This study aims to determine the impact of training program to the improvement of teaching competency in Adaptive Physical Education (APE) of special educators. The provided training is competency-based and conventional training program.
Komar Hidayat
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Keypoint Detection Based on Curvature Grouping and Adaptive Sampling

IEEE Access
In the keypoint detection algorithm, the farthest point sampling methods and random sampling methods are usually used to select candidate points, then keypoints are screened out from the neighborhood of the candidate points.
Bifu Li, Yu Cheng, Weitong Li
doaj   +1 more source

The Effect of Cognitive and Cognitive–Meta Cognitive Education Strategies on Problem Solving Ability and Adaptive Behavior of Mentally Retarded Students [PDF]

Ravānshināsī-i Afrād-i Istis̠nāyī, 2013
The present study aims at investigating the effects of cognitive and cognitive–meta cognitive education strategies on problem solving ability and adaptive behavior of mentally retarded students in junior professional schools.
Alireza Mohammadi Arya, Maryam Seyf Naraqi, Ali Delavar, Esmail Sa’dipour   +3 more
doaj