Results 131 to 140 of about 2,359,184 (334)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
A novel adaptive PID controller with new seesaw algorithms using alternative derivatives
Systems Science & Control EngineeringThe [Formula: see text] controller is present in at least 90% of industrial applications due to its simplicity and robustness to control linear and non-linear systems.
Juan Pablo Manzo Hernández +4 more
doaj +1 more source
Identification and dual adaptive control of a turbojet engine [PDF]
The objective of this paper is to utilize the design methods of modern control theory to realize a dual-adaptive feedback control unit for a highly nonlinear single spool airbreathing turbojet engine.
Leininger, G., Merrill, W.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
System Dynamics and Adaptive Control for MEMS Gyroscope Sensor
International Journal of Advanced Robotic Systems, 2011 This paper presents an adaptive control approach for Micro-Electro-Mechanical Systems (MEMS) z-axis gyroscope sensor. The dynamical model of MEMS gyroscope sensor is derived and adaptive state tracking control for MEMS gyroscope is developed.
Juntao Fei, Hongfei Ding
doaj
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Distributed adaptive time‐varying formation of multi‐UAV systems under undirected graph
IET Intelligent Transport SystemsIn this paper, a fully distributed control protocol is presented based on adaptive technology to solve the time‐varying formation problem of multi‐unmanned aerial vehicle (UAV) systems, where the coupling weights between neighbouring UAVs can be adjusted
Xin Cai, Xiaozhou Zhu, Wen Yao
doaj +1 more source