Results 81 to 90 of about 173,678 (265)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

From regime shifts to adaptive cycles: dynamic understanding of human-water system

Environmental Research: Water
Human-water systems are constantly changing over time. Regime shifts encompass large, abrupt and persistent structural and functional changes, leading the system to new reinforced processes or feedbacks. While existing research focuses on detecting early
Shuang Song, Lian Zhang, Jürgen Renn, Patrick Roberts   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sustainable Development Integrated in the Concept of Resilence

Problemy Ekorozwoju, 2015
The purpose of sustainable development is to minimize the likelihood of dynamic natural and/or man-made systems to exceed tipping points, when exposed to disturbances. In effect, the systems are protected from losing identity and integrity.
Jürg Bloesch, Michael von Hauff, Klaus Mainzer, S. Venkata Mohan, Ortwin Renn, Verena Risse, Yonghui Song, Kazuhiko Takeuchi, Peter A. Wilderer   +8 more
doaj  

Estimation of SOC in Lithium-Iron-Phosphate Batteries Using an Adaptive Sliding Mode Observer with Simplified Hysteresis Model during Electric Vehicle Duty Cycles

Batteries
This paper develops a model for lithium-ion batteries under dynamic stress testing (DST) and federal urban driving schedule (FUDS) conditions that incorporates associated hysteresis characteristics of 18650-format lithium iron-phosphate batteries ...
Yujia Chang, Ran Li, Hao Sun, Xiaoyu Zhang   +3 more
doaj   +1 more source

Revolt and Remember: How the Shimshal Nature Trust Develops and Sustains Social-Ecological Resilience in Northern Pakistan

Ecology and Society, 2007
The Shimshal Nature Trust is an indigenous institution rooted in a thriving and dynamic culture that links the local ecology and society. It has deployed identity, traditional knowledge, science, and institutional innovation to adapt to outside ...
Mehjabeen Abidi-Habib, Anna Lawrence
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Intelligent Energy Management Strategy for PHEV with Adaptive Rule-Parameter Updating

World Electric Vehicle Journal
To address the poor adaptability to diverse driving cycles and the imbalance between optimization performance and computational efficiency in existing energy management strategies (EMSs) for plug-in hybrid electric vehicles (PHEVs), this paper proposes a
Ling Li, Jun Chen, Tao Zhou, Binao Chen
doaj   +1 more source