Results 61 to 70 of about 565,752 (296)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Palliative expeditiously adaptive quad shot radiotherapy for head and neck cancers (PEAQ-RT)

Clinical and Translational Radiation Oncology
Purpose/objective: Quad shot radiotherapy (QS-RT) is integral to head and neck cancer palliative care, but multiple CT-simulations for QS-RT cycles can be burdensome for patients. We evaluated the ability of an online adaptive radiotherapy (ART) workflow
Weiren Liu, Joshua P. Schiff, Comron Hassanzadeh, Karen Miller, Casey Hatscher, Robbie Beckert, Alex Price, Mackenzie Daly, Randall Brenneman, Lauren Henke, Anthony Apicelli, Michael Moravan, Wade Thorstad, Eric Laugeman   +13 more
doaj   +1 more source

Minor variations in multicellular life cycles have major effects on adaptation.

PLoS Computational Biology, 2023
Multicellularity has evolved several independent times over the past hundreds of millions of years and given rise to a wide diversity of complex life. Recent studies have found that large differences in the fundamental structure of early multicellular ...
Hanna Isaksson, Åke Brännström, Eric Libby   +2 more
doaj   +1 more source

Implementation of Driving Cycles Based on Driving Style Characteristics of Autonomous Vehicles

World Electric Vehicle Journal, 2022
The standardized driving cycles, which are used around the globe for the development and homologation of automobiles, consist of a series of speed points versus time, to represent typical driving conditions and to exclude the influence of a human driver.
Xucheng Duan, Ferdinand Schockenhoff, Alexander Koch   +2 more
doaj   +1 more source

Adaptive negative cycle detection in dynamic graphs [PDF]

ISCAS 2001. The 2001 IEEE International Symposium on Circuits and Systems (Cat. No.01CH37196), 2001
We examine the problem of detecting negative cycles in a dynamic graph, which is a fundamental problem that arises in electronic design automation and systems theory. We introduce the concept of adaptive negative cycle detection, in which a graph changes over time, and negative cycle detection needs to be done periodically, but not necessarily after ...
Nitin Chandrachoodan, Shuvra S. Bhattacharyya, K. J. Ray Liu   +2 more
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Modeling CD4+ T cells dynamics in HIV-infected patients receiving repeated cycles of exogenous Interleukin 7 [PDF]

, 2016
Combination Antiretroviral Therapy (cART) succeeds to control viral replication in most HIV infected patients. This is normally followed by a reconstitution of the CD4$^+$ T cells pool; however, this does not happen for a substantial proportion of ...
Commenges, Daniel, Jarne, Ana, Levy, Yves, Prague, Mélanie, Thiébaut, Rodolphe   +4 more
core   +2 more sources

Adaptive weight estimator for quantum error correction [PDF]

, 2017
Quantum error correction of a surface code or repetition code requires the pairwise matching of error events in a space-time graph of qubit measurements, such that the total weight of the matching is minimized.
Beenakker, C. W. J., O'Brien, T. E., Spitz, S. T., Tarasinski, B.   +3 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source