Results 61 to 70 of about 173,678 (265)

A Process-Variation-Adaptive Network-on-Chip with Variable-Cycle Routers and Variable-Cycle Pipeline Adaptive Routing [PDF]

IEICE Transactions on Electronics, 2012
As process technology is scaled down, a typical system on a chip (SoC) becomes denser. In scaled process technology, process variation becomes greater and increasingly affects the SoC circuits. Moreover, the process variation strongly affects network-on-chips (NoCs) that have a synchronous network across the chip.
Yohei Nakata, Hiroshi Kawaguchi 0001, Masahiko Yoshimoto   +2 more
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Palliative expeditiously adaptive quad shot radiotherapy for head and neck cancers (PEAQ-RT)

Clinical and Translational Radiation Oncology
Purpose/objective: Quad shot radiotherapy (QS-RT) is integral to head and neck cancer palliative care, but multiple CT-simulations for QS-RT cycles can be burdensome for patients. We evaluated the ability of an online adaptive radiotherapy (ART) workflow
Weiren Liu, Joshua P. Schiff, Comron Hassanzadeh, Karen Miller, Casey Hatscher, Robbie Beckert, Alex Price, Mackenzie Daly, Randall Brenneman, Lauren Henke, Anthony Apicelli, Michael Moravan, Wade Thorstad, Eric Laugeman   +13 more
doaj   +1 more source

Latitudinal and zoo specific zeitgebers influence circadian and circannual rhythmicity of behavior in captive giant pandas (Ailuropoda melanoleuca)

Frontiers in Psychology, 2023
IntroductionThe circadian clock influences many aspects of animal welfare including metabolism, breeding, and behavior. In most species, circadian clocks are internal clocks regulated by external environmental cues called zeitgebers.
Kristine M. Gandia, Sharon E. Kessler, Hannah M. Buchanan-Smith   +2 more
doaj   +1 more source

Adaptive negative cycle detection in dynamic graphs [PDF]

ISCAS 2001. The 2001 IEEE International Symposium on Circuits and Systems (Cat. No.01CH37196), 2001
We examine the problem of detecting negative cycles in a dynamic graph, which is a fundamental problem that arises in electronic design automation and systems theory. We introduce the concept of adaptive negative cycle detection, in which a graph changes over time, and negative cycle detection needs to be done periodically, but not necessarily after ...
Nitin Chandrachoodan, Shuvra S. Bhattacharyya, K. J. Ray Liu   +2 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Minor variations in multicellular life cycles have major effects on adaptation.

PLoS Computational Biology, 2023
Multicellularity has evolved several independent times over the past hundreds of millions of years and given rise to a wide diversity of complex life. Recent studies have found that large differences in the fundamental structure of early multicellular ...
Hanna Isaksson, Åke Brännström, Eric Libby   +2 more
doaj   +1 more source