Results 61 to 70 of about 2,040,374 (260)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Partisan cycles and pre-electoral uncertainty [PDF]
Rational partisan theory of political business cycles suggests differences in inflation under left-wing and right-wing governments. It also suggests temporary post-electoral booms after election of left-wing governments and temporary recessions after ...
Berlemann, Michael, Markwardt, Gunther
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
From regime shifts to adaptive cycles: dynamic understanding of human-water system
Environmental Research: WaterHuman-water systems are constantly changing over time. Regime shifts encompass large, abrupt and persistent structural and functional changes, leading the system to new reinforced processes or feedbacks. While existing research focuses on detecting early
Shuang Song +3 more
doaj +1 more source
Physics and Imaging in Radiation OncologyBackground and purpose: Adaptive Four-Dimensional Cone-Beam Computed Tomography (4DCBCT) can reduce scan time and imaging dose in radiotherapy. This is achieved by modulating the projection acquisition rate and gantry rotation speed in response to real ...
Sadia Sana +11 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Cycles and Common Cycles in Property and Related Sectors [PDF]
This paper examines cycles and common cycles in the property market and the economy. While focusing on common cycles, the study also incorporates common trends in the meantime, so it covers the whole spectrum of dynamic analysis.
Peijie Wang
core
Sustainable Development Integrated in the Concept of Resilence
Problemy Ekorozwoju, 2015 The purpose of sustainable development is to minimize the likelihood of dynamic natural and/or man-made systems to exceed tipping points, when exposed to disturbances. In effect, the systems are protected from losing identity and integrity.
Jürg Bloesch +8 more
doaj