Results 91 to 100 of about 1,920,879 (284)

Acknowledgment to Reviewers of Designs in 2020

, 2021
Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Designs maintains its standards for the high quality of its published papers [...
Designs Editorial Office Designs Editorial Office
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Adaptive trials in low back pain and osteoarthritis: How common are they and when should they be used? A systematic review from ClinicalTrials.gov

Osteoarthritis and Cartilage Open
Objective: This registry-based systematic review aimed to investigate the use and applicability of adaptive designs in ongoing low back pain (LBP) and osteoarthritis (OA) trials and discuss emerging opportunities of adaptive designs in the field, in ...
Anelise Moreti Cabral Silveira, Michelle Wang, Michelle Hall, Manuela L. Ferreira, Paula R. Beckenkamp, Thomas Snelling, Serigne N. Lo, Laurent Billot, James M.S. Wason, Haiyan Zheng, Paulo H. Ferreira   +10 more
doaj   +1 more source

Adaptive design methods in clinical trials – a review

Orphanet Journal of Rare Diseases, 2008
In recent years, the use of adaptive design methods in clinical research and development based on accrued data has become very popular due to its flexibility and efficiency.
Chang Mark, Chow Shein-Chung
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Alabama road map and directory, Tempo Designs, Chicago, Illinois 1975-76

, 1975
The digitization of this collection was funded by a gift from EBSCO ...
Tempo Designs
core  

Context-Adaptive Learning Designs by Using Semantic Web Services

Journal of Interactive Media in Education, 2007
IMS Learning Design (IMS-LD) is a promising technology aimed at supporting learning processes. IMS-LD packages contain the learning process metadata as well as the learning resources.
Stefan Dietze, Alessio Gugliotta, John B. Domingue   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Value-adaptive clinical trial designs for efficient delivery of publicly funded trials - a discussion of methods, case studies, opportunities and challenges

BMC Medical Research Methodology
Background Value-adaptive designs for clinical trials are a novel set of emerging methods for delivering greater value for clinical research. There is increasing interest in using them within publicly funded health systems.
Laura Flight, Alan Brennan, Stephen E. Chick, Martin Forster, Steven Julious, Puvan Tharmanathan   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source