Results 81 to 90 of about 1,920,879 (284)
Individually adapted sequential Bayesian designs for conjoint choice experiments. [PDF]
In this paper, we propose an efficient individually adapted sequential Bayesian approach for constructing conjoint choice experiments. It uses Bayesian updating, a Bayesian analysis and a Bayesian design criterion for generating choice-set-designs for ...
Goos, Peter +2 more
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Critical concepts in adaptive clinical trials
Clinical Epidemiology, 2018 Jay JH Park,1 Kristian Thorlund,2,3 Edward J Mills2,3 1Department of Medicine, University of British Columbia, Vancouver, BC, Canada; 2Department of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, ON, Canada; 3The Bill
Park JJH, Thorlund K, Mills EJ
doaj
ADAPTABLE DESIGN FOR DESIGN REUSE
Proceedings of the Canadian Engineering Education Association (CEEA), 2011 Due to the complexity, associated cost, and general uncertainty of performing the creative design process, significant value exists in reusing the design information developed in previous design efforts. This paper outlines the current state of the art in design reuse in various fields as well as identifying both the current and future research areas ...
D. Fletcher, P. Gu
openaire +2 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Practical considerations for optimal designs in clinical dose finding studies [PDF]
Determining an adequate dose level for a drug and, more broadly, characterizing its dose response relationship, are key objectives in the clinical development of any medicinal drug. If the dose is set too high, safety and tolerability problems are likely
Dette, Holger +2 more
core
Play-the-winner rule and adaptive designs of clinical trials
International Journal of Mathematics and Mathematical Sciences, 2001 In another paper, we have argued that the traditional randomized design of clinical trials is ethically infeasible in desperate medical situations and adaptive designs are morally required.
Xikui Wang, Daryl Pullman
doaj +1 more source
Adaptive Allocation Designs for Normal and Binary Treatment Responses
Austrian Journal of Statistics, 2019 A class of adaptive designs is formulated in two stages for clinical trials to favour the better performing treatment for further allocation in an efficient way.
Madhumita Shome, Rahul Bhattacharya
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source