Results 61 to 70 of about 1,920,879 (284)
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen +10 more
wiley +1 more source
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families guide the provision of comprehensive psychosocial care. Parallel to research characterizing implementation of the Standards from the perspective of providers, this study examines implementation of the Standards from the perspective of parents of youth ...
Emily M. Pariseau +8 more
wiley +1 more source
Adaptive design in clinical trials: benefits and risks
Over the past several decades, adaptive design methods in clinical trials has become more popular as a way to increase the efficiency of the early and late phases of clinical development by means of reducing costs, resources and duration as well as ...
I. B. Bondareva
doaj
Background The application of adaptive design methodology within a clinical trial setting is becoming increasingly popular. However the application of these methods within trials is not being reported as adaptive designs hence making it more difficult to
Pankaj Mistry +2 more
doaj +1 more source
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba +29 more
wiley +1 more source
IMS LD reusable elements for adaptive learning designs
Commentary on: Chapter 12: Designing Adaptive Learning Environments with Learning Design. (Towle & Halm, 2005)Abstract: This paper presents an approach to designing adaptive learning environments based on IMS LD, which separates its elements (i.e ...
Adriana J. Berlanga +1 more
doaj +1 more source
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine +21 more
wiley +1 more source
Adaptive designs based on the truncated product method
Background Adaptive designs are becoming increasingly important in clinical research. One approach subdivides the study into several (two or more) stages and combines the p-values of the different stages using Fisher's combination test.
Neuhäuser Markus, Bretz Frank
doaj +1 more source
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye +33 more
wiley +1 more source
Adaptive multivariate global testing [PDF]
We present a methodology for dealing with recent challenges in testing global hypotheses using multivariate observations. The proposed tests target situations, often arising in emerging applications of neuroimaging, where the sample size n is relatively ...
Aston, John A. D. +3 more
core +1 more source

