Results 41 to 50 of about 1,920,879 (284)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Bayesian Adaptive Designs for Clinical Trials [PDF]
, 2018 A Bayesian adaptive design is proposed for a comparative two-armed clinical trial using decision theoretical approaches. A loss function is specified to consider the costfor each patient, and the costs of making incorrect decisions at the end of a trial.
Cheng, Yi, Shen, Yu
core +1 more source
SAGE Open Medicine, 2017 Objectives: Clinical trials are complicated, expensive, time-consuming, and frequently do not lead to discoveries that improve the health of patients with disease.
Timothy C Guetterman +7 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom +15 more
wiley +1 more source
Benefits, challenges and obstacles of adaptive clinical trial designs
Orphanet Journal of Rare Diseases, 2011 In recent years, the use of adaptive design methods in pharmaceutical/clinical research and development has become popular due to its flexibility and efficiency for identifying potential signals of clinical benefit of the test treatment under ...
Chow Shein-Chung, Corey Ralph
doaj +1 more source
Threshold Designer Adaptation: Improved Adaptation for Designers in Co-creative Systems
Proceedings of the Thirty-First International Joint Conference on Artificial Intelligence, 2022 To best assist human designers with different styles, Machine Learning (ML) systems need to be able to adapt to them. However, there has been relatively little prior work on how and when to best adapt an ML system to a co-designer. In this paper we present threshold designer adaptation: a novel method for adapting a creative ML model to an individual ...
Emily Halina, Matthew Guzdial
openaire +4 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld +5 more
wiley +1 more source
Modern Clinical Trials: Seamless Designs and Master Protocols
Cancer MedicineBackground Drug development is often inefficient, costly and lengthy, yet it is essential for evaluating the safety and efficacy of new interventions. Compared with other disease areas, this is particularly true for Phase II/III cancer clinical trials ...
Abigail Burdon +5 more
doaj +1 more source
Adaptive designs in clinical trials: why use them, and how to run and report them
BMC Medicine, 2018 Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules.
Philip Pallmann +15 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo +9 more
wiley +1 more source