Results 31 to 40 of about 1,920,879 (284)

New clinical trial designs in the era of precision medicine

Molecular Oncology, 2019
Cancer treatment has made significant strides towards the promise of personalized medicine. Recent scientific advances have shown that there are numerous genetic deregulations that are common in multiple cancer types, raising the possibility of ...
Elena Garralda, Rodrigo Dienstmann, Alejandro Piris‐Giménez, Irene Braña, Jordi Rodon, Josep Tabernero   +5 more
doaj   +1 more source

Adaptive trial designs: a review of barriers and opportunities

Trials, 2012
Adaptive designs allow planned modifications based on data accumulating within a study. The promise of greater flexibility and efficiency stimulates increasing interest in adaptive designs from clinical, academic, and regulatory parties.
Kairalla John A, Coffey Christopher S, Thomann Mitchell A, Muller Keith E   +3 more
doaj   +1 more source

Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review.

PLoS ONE, 2016
BackgroundPersonalized medicine is a growing area of research which aims to tailor the treatment given to a patient according to one or more personal characteristics. These characteristics can be demographic such as age or gender, or biological such as a
Miranta Antoniou, Andrea L Jorgensen, Ruwanthi Kolamunnage-Dona   +2 more
doaj   +1 more source

Evolution of clinical trials: An overview on adaptive designs

Journal of Current Research in Scientific Medicine
Adaptive clinical trials are innovative study designs having flexibility and the ability to adapt its trial features and course for efficiency depending on the accumulating data from the trial itself.
Shanmugarajan Dayanidhi, Dharam Prasath
doaj   +1 more source

Optimal designs for full and partial likelihood information - with application to survival models [PDF]

, 2015
Time-to-event data are often modelled through Cox's proportional hazards model for which inference is based on the partial likelihood function. We derive a general expression for the asymptotic covariance matrix of Cox's partial likelihood estimator for ...
Konstantinou, Maria, Kimber, Alan C., Biedermann, S., Biedermann, Stefanie   +3 more
core   +1 more source

Targeted Adaptive Design

SIAM/ASA Journal on Uncertainty Quantification
SIAM/ASA Journal on Uncertainty Quantification, Accepted ...
Carlo Graziani, Marieme Ngom
openaire   +2 more sources

Optimal designs for indirect regression [PDF]

, 2004
In many real life applications, it is impossible to observe the feature of interest directly. For example, scientists in Materials Science may be interested in detecting cracks inside objects, not visible from the outside. Similarly, non-invasive medical
Edmund Jones, G. Vitale, Osses Alvarado, Axel, Nicolai Bissantz, Vitale, Guido, Cumsille, Patricio, Takahashi, Takéo, Hajo Holzmann, Chern, I-Liang, Conca, Carlos, Preziosi, Luigi, Kavian, O., L. Preziosi, Zuo, D., Langer, Matthias, Censor, Yair, Mueller, J. L., Ambrosi, Davide Carlo, Malik, Muslim, Schwindt, Erica L., Anthony Dubois, Herrera, C. N. L., Bissantz, Nicolai, Hamilton, S. J., Horng-Shing Lu, Henry, Pierro, Álvaro Rodolfo De, Schwindt, Erica, Rosier, Lionel, Helou Neto, Elias Salomão, Muslim Malik, Marc Saillard, Cheney, Margaret, Jiang, Ming, Kawano, Alexandre, Kamal Belkebir, Dette, Holger, Alvarez, Catalina, Von Herrmann, A., Holger Dette, Monard, F., Margaret Cheney, Holzmann, Hajo, Courdurier Bettancourt, Matías, Borden, Brett, Friz, L., Pandolfi, Luciano, Chen, Tai-Been, Romero, F., Brett Borden, Stefanie Biedermann, Conca Rosende, Carlos, Munnier, Alexandre, Ortega Palma, Jaime, Jones, Edmund, Woracek, Harald, Carlos Conca, Biedermann, Stefanie, Hamilton, Sarah J., Alexandre Munnier   +58 more
core   +1 more source

Adaptive Clinical Trial Designs for Phase I Cancer Studies

, 2014
Adaptive clinical trials are becoming increasingly popular research designs for clinical investigation. Adaptive designs are particularly useful in phase I cancer trials where clinical data are scant, and the goals are to assess the drug dose-toxicity ...
Wong, Weng Kee, Ryeznik, Yevgen, Sverdlov, Oleksandr   +2 more
core   +1 more source

On adaptive optimal input design

2003 European Control Conference (ECC), 2003
The problem of optimal input design for a specific fedbatch bioreactor case study is solved recursively. Hereto an adaptive receding horizon optimal control problem, involving the so-called E-criterion, is solved ‘on-line’, using the current estimate of the parameter vector θ at each sample instant {t k , k = 0,…, N − h}, where N marks the end of the ...
Stigter, J.D., Vries, D., Keesman, K.J.
openaire   +4 more sources

Value of Adaptive Trials and Surrogate Endpoints for Clinical Decision-Making in Rare Cancers

Frontiers in Oncology, 2021
Despite high-level endorsement, the number of adaptive Phase II/III trials in rare cancers needs to be improved, with better understanding of their value for clinical decisions in daily practice.
Andriy Krendyukov, Sanjay Singhvi, Markus Zabransky   +2 more
doaj   +1 more source