Results 21 to 30 of about 1,920,879 (284)
CHIMIA, 2013 Computer algorithms help in the identification and optimization of peptides with desired structure and function. We provide an overview of the current focus of our research group in this field, highlighting innovative methods for peptide representation and de novo peptide generation.
Schneider Gisbert +6 more
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CoRR, 2018 We present a probabilistic modeling framework and adaptive sampling algorithm wherein unsupervised generative models are combined with black box predictive models to tackle the problem of input design. In input design, one is given one or more stochastic "oracle" predictive functions, each of which maps from the input design space (e.g.
David H. Brookes, Jennifer Listgarten
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Contemporary Clinical Trials Communications, 2023 Background: As we enter the era of precision medicine, the role of adaptive designs, such as response-adaptive randomisation or enrichment designs in drug discovery and development, has become increasingly important to identify the treatment given to a ...
Valentin Vinnat +3 more
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The R Package MAMS for Designing Multi-Arm Multi-Stage Clinical Trials
Journal of Statistical Software, 2019 In the early stages of drug development there is often uncertainty about the most promising among a set of different treatments, different doses of the same treatment, or combinations of treatments.
Thomas Jaki +2 more
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A comparison of clinical development pathways to advance tuberculosis regimen development
BMC Infectious Diseases, 2022 Background Current tuberculosis (TB) regimen development pathways are slow and in urgent need of innovation. We investigated novel phase IIc and seamless phase II/III trials utilizing multi-arm multi-stage and Bayesian response adaptive randomization ...
V. Chang +4 more
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A tool for adaptive lighting design [PDF]
Proceedings of the 2008 ACM SIGGRAPH symposium on Video games, 2008 Filmmakers, theater directors, and designers take extreme care in aesthetically composing their scenes. This sense of aesthetics is important to promote presence, immersion, and involvement. Video games have adopted many design theories and techniques from linear media, particularly film. However, interactive environments are dynamic and unpredictable,
Zupko, Joseph, Seif El-Nasr, Magy
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Adaptation as organism design [PDF]
Biology Letters, 2009 The problem of adaptation is to explain the apparent design of organisms. Darwin solved this problem with the theory of natural selection. However, population geneticists, whose responsibility it is to formalize evolutionary theory, have long neglected the link between natural selection and organismal design.
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Reducing the patients-at-risk (PaR) in a response-adaptive trial: A numerical study
IIMB Management Review, 2023 This article investigates the dichotomy between higher statistical power and higher allocation to better treatment in an ethical-optimal response-adaptive design.
L. Ramprasath, Mohammed Shahid Abdulla
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BMJ Medicine, 2022 Randomised controlled clinical trials are widely considered the preferred method for evaluating the efficacy or effectiveness of interventions in healthcare.
Robert J Glynn +5 more
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Test Strategies for Multi-Voltage Designs [PDF]
, 2009 Reducing the power consumption of digital designs through the use of more than one Vdd value (Multi-Voltage) is known and well practiced. Some manufacturing defects have Vdd-dependency, which implies defects can become active only at certain power supply
Khursheed, Syed Saqib +1 more
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