Improving clinical trials using Bayesian adaptive designs: a breast cancer example [PDF]
BMC Medical Research Methodology, 2022 Background To perform virtual re-executions of a breast cancer clinical trial with a time-to-event outcome to demonstrate what would have happened if the trial had used various Bayesian adaptive designs instead.
Wei Hong +3 more
doaj +2 more sources
Optimizing dose-schedule regimens with bayesian adaptive designs: opportunities and challenges [PDF]
Frontiers in Pharmacology, 2023 Due to the small sample sizes in early-phase clinical trials, the toxicity and efficacy profiles of the dose-schedule regimens determined for subsequent trials may not be well established.
Xin Chen +4 more
doaj +2 more sources
Bayesian adaptive designs for multi-arm trials: an orthopaedic case study [PDF]
Trials, 2020 Background Bayesian adaptive designs can be more efficient than traditional methods for multi-arm randomised controlled trials. The aim of this work was to demonstrate how Bayesian adaptive designs can be constructed for multi-arm phase III clinical ...
Elizabeth G. Ryan +3 more
doaj +2 more sources
Adaptive designs in critical care trials: a simulation study [PDF]
BMC Medical Research Methodology, 2023 Background Adaptive clinical trials are growing in popularity as they are more flexible, efficient and ethical than traditional fixed designs. However, notwithstanding their increased use in assessing treatments for COVID-19, their use in critical care ...
W. Li +4 more
doaj +2 more sources
An Overview of Adaptive Designs and Some of Their Challenges, Benefits, and Innovative Applications [PDF]
Journal of Medical Internet Research, 2023 Adaptive designs are increasingly developed and used to improve all phases of clinical trials and in biomedical studies in various ways to address different statistical issues.
Hongjian Zhu, Weng Kee Wong
doaj +2 more sources
Adaptive designs for trials aiming to optimise implementation strategies and the effect of an additional interim analysis: a simulation study [PDF]
BMC Medical Research MethodologyTrials that aim to optimise the implementation of an intervention are often complex, requiring multiple, combined strategies and requiring uptake on multiple levels.
Erin Nolan +5 more
doaj +2 more sources
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs [PDF]
BMC Medicine, 2020 Adaptive designs for clinical trials permit alterations to a study in response to accumulating data in order to make trials more flexible, ethical, and efficient.
Thomas Burnett +5 more
doaj +2 more sources
Using Bayesian adaptive designs to improve phase III trials: a respiratory care example [PDF]
BMC Medical Research Methodology, 2019 Background Bayesian adaptive designs can improve the efficiency of trials, and lead to trials that can produce high quality evidence more quickly, with fewer patients and lower costs than traditional methods.
Elizabeth G. Ryan +7 more
doaj +2 more sources
When to keep it simple – adaptive designs are not always useful [PDF]
BMC Medicine, 2019 Background Adaptive designs are a wide class of methods focused on improving the power, efficiency and participant benefit of clinical trials.
James M. S. Wason +2 more
doaj +2 more sources
Characterization of medical device randomized controlled trials with adaptive designs [PDF]
Journal of Comparative Effectiveness ResearchAim: Adaptive designs are frequently used in drug randomized controlled trials (RCTs). However, their use in medical device RCTs remains unclear. We aimed to characterize medical device RCTs with adaptive designs.
Gui Su +4 more
doaj +2 more sources