Results 11 to 20 of about 1,920,879 (284)
Annual Review of Pharmacology and Toxicology, 2012 We review adaptive designs for clinical trials, giving special attention to the control of the Type I error in late-phase confirmatory trials, when the trial planner wishes to adjust the final sample size of the study in response to an unblinded analysis of interim estimates of treatment effects. We point out that there is considerable inefficiency in
Tze Leung, Lai +2 more
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Adaptive designs in clinical trials
Perspectives in Clinical Research, 2011 In addition to the expensive and lengthy process of developing a new medicine, the attrition rate in clinical research was on the rise, resulting in stagnation in the development of new compounds.
Suresh Bowalekar
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Bayesian adaptive designs for the optimisation of implementation strategies: a virtual re-execution of the Physically Active Children in Education (PACE) trials [PDF]
Implementation Science CommunicationsBackground Current designs used to optimise implementation strategies (e.g., sequential cluster randomised controlled trials (cRCTs) and multi-arm cRCTs) are inefficient and resource intensive.
Erin Nolan +6 more
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Adaptive designs in clinical trials: a systematic review-part I [PDF]
BMC Medical Research MethodologyBackground Adaptive designs (ADs) are intended to make clinical trials more flexible, offering efficiency and potentially cost-saving benefits. Despite a large number of statistical methods in the literature on different adaptations to trials, the ...
Mohamed Ben-Eltriki +14 more
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Authoring courses with rich adaptive sequencing for IMS learning design [PDF]
, 2008 This paper describes the process of translating an adaptive sequencing strategy designed using Sequencing Graphs to the semantics of IMS Learning Design. The relevance of this contribution is twofold.
Gutierrez-Santos, Sergio +2 more
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Adaptive Incentive Design [PDF]
IEEE Transactions on Automatic Control, 2021 We apply control theoretic and optimization techniques to adaptively design incentives. In particular, we consider the problem of a planner with an objective that depends on data from strategic decision makers. The planner does not know the process by which the strategic agents make decisions. Under the assumption that the agents are utility maximizers,
Lillian J. Ratliff, Tanner Fiez
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Adaptive designs for clinical trials
Kerala Journal of Ophthalmology, 2021 The gold standard for interventional studies is the randomized controlled trial (RCT). The RCT follows a linear path with prespecified plans and a little option for flexibility within its implementation.
Praveen K Nirmalan
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Stakeholder perspectives on adaptive clinical trials: a scoping review
Trials, 2020 Background Adaptive clinical trials (ACTs) represent an emerging approach to trial design where accumulating data are used to make decisions about future conduct. Adaptations can include comparisons of multiple dose tiers, response-adaptive randomization,
Tina Madani Kia +2 more
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Designer adaptation in adaptive hypermedia authoring [PDF]
Proceedings ITCC 2003. International Conference on Information Technology: Coding and Computing, 2004 Recently, the importance of creating authoring support for adaptive hypermedia system design offering multimodality and personalization is becoming evident. In the process of designing such authoring support, we discovered that given the difficulty of adaptive hypermedia authoring, i.e., in designing different levels of abstraction, alternatives ...
Alexandra I. Cristea, Arnout de Mooij
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Software tools for implementing simulation studies in adaptive seamless designs : introducing R package ASD [PDF]
, 2011 Adaptive designs for clinical trials have the potential to improve the efficiency of clinical research by, for instance, seamlessly combining different stages of a clinical development ...
Friede, Tim +8 more
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