Results 71 to 80 of about 405,051 (265)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Adaptive Agents Applied to Intrusion Detection [PDF]

, 2007
This paper proposes a system of agents that make predictions over the presence of intrusions. Some of the agents act as predictors implementing a given Intrusion Detection model, sniffing out the same traffic. An assessment agent weights the forecasts of such predictor agents, giving a final binary conclusion using a probabilistic model.
Javier Carbo Rubiera, Agustín Orfila, Arturo Ribagorda   +2 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Low-Illumination Parking Scenario Detection Based on Image Adaptive Enhancement

World Electric Vehicle Journal
Aiming at the problem of easily missed and misdetected parking spaces and obstacles in the automatic parking perception task under low-illumination conditions, this paper proposes a low-illumination parking space and obstacle detection algorithm based on
Xixi Xu, Meiqi Zhang, Hao Tang, Weiye Xu, Bowen Sun, Zhu’an Zheng   +5 more
doaj   +1 more source

Online process monitoring and fault-detection approach based on adaptive neighborhood preserving embedding

Measurement + Control, 2019
This study aims to solve the problem involving the high false alarm rate experienced during the detection process when using the traditional multivariate statistical process monitoring method.
Lei Tan, Peng Li, Aimin Miao, Yong Chen
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Zero-day exploits detection with adaptive WavePCA-Autoencoder (AWPA) adaptive hybrid exploit detection network (AHEDNet)

Scientific Reports
This paper introduces a new probabilistic composite model for the detection of zero-day exploits targeting the capabilities of existing anomaly detection systems in terms of accuracy, computational time, and adaptability.
Ahmed A. Mohamed, Abdullah Al-Saleh, Sunil Kumar Sharma, Ghanshyam G. Tejani   +3 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source