Results 121 to 130 of about 33,794 (307)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

A Kernel-based Real-time Adaptive Dynamic Programming Method for Economic Household Energy Systems

, 2022
A Kernel-based Real-time Adaptive Dynamic Programming Method for Economic Household Energy ...
Samson Yu (13093116), Sizhe Chen (10886739), Jun Yuan (356273), Yun Zhang (131894), Guidong Zhang (13481305), Zhe Chen (196097)   +5 more
core  

ADP-Based H_∞ Optimal Control of Robot Manipulators With Asymmetric Input Constraints and Disturbances

IEEE Access
Trajectory tracking control for robot manipulators is an attractive topic in the research community. This is a challenging problem because robot manipulators are complex nonlinear systems.
Dien Nguyen Duc, Lai Lai Khac, Luy Nguyen Tan   +2 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Discrete Adaptive Optimal Control Based Multi-Dimensional Taylor Networks Within Iterative Learning Framework

Kongzhi Yu Xinxi Jishu
General nonlinear discrete systems are characterized by high nonlinearity, model uncertainties, and unknown dynamics. Traditional control methods typically rely on a simplified or linearized model to represent the actual system, which leads to inherent ...
ZHANG Chao, SUN Qiming, QIU Yaqin
doaj  

Multi-disciplinary optimization of underwater vehicles based on a dynamic proxy model

Brodogradnja
This paper presents a method for optimizing the multidisciplinary shape design of underwater vehicles using a dynamic proxy model. The method employs a collaborative optimization approach that considers various disciplines, including rapidity ...
Shaojun Sun, Weilin Luo
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Continuous adaptive critic designs

, 2005
A continuous formulation of an adaptive critic design (ACD) is investigated. Connections to the discrete case are made, where backpropagation through time (BPTT) and realtime recurrent learning (RTRL) are prevalent. A second order actor adaptation, based
Hanselmann, T., Noakes, L., Zaknich, A.
core  

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Supporting authoring of adaptive hypermedia [PDF]

It is well-known that students benefit from personalised attention. However, frequently teachers are unable to provide this, most often due to time constraints.
Hendrix, Maurice
core