Results 91 to 100 of about 1,011,945 (297)

The diplomat's dilemma: Maximal power for minimal effort in social networks

, 2008
Closeness is a global measure of centrality in networks, and a proxy for how influential actors are in social networks. In most network models, and many empirical networks, closeness is strongly correlated with degree.
A Barrat, D Kahneman, D Knoke, DJ Watts, G Ehrhardt, G Sabidussi, K Lindgren, K Nakao, LM Valen van, M Nowak, M Rosvall, M Rosvall, M Weber, MA Nowak, MEJ Newman, MO Jackson, P Erdős, P Holme, P Holme, P Holme, PW Holland, R Albert, R Axelrod, S Gila, SN Dorogovtsev, T Gross, V Bala   +26 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Symmetric competition as a general model for single-species adaptive dynamics

, 2012
Adaptive dynamics is a widely used framework for modeling long-term evolution of continuous phenotypes. It is based on invasion fitness functions, which determine selection gradients and the canonical equation of adaptive dynamics.
Doebeli, Michael, Ispolatov, Iaroslav
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Adaptive TreePM: An Adaptive Resolution Code for Cosmological N-body Simulations

, 2009
Cosmological N-Body simulations are used for a variety of applications. Indeed progress in the study of large scale structures and galaxy formation would have been very limited without this tool.
Athanassoula, Bagla, Bagla, Bagla, Bagla, Bagla, Bagla, Bagla, Bagla, Bagla, Bagla, Barnes, Barnes, Bernardeau, Bertschinger, Binney, Binney, Bode, Bode, Bouchet, Bouchet, Bouchet, Brainerd, Brieu, Brieu, Couchman, Couchman, Davis, Dehnen, Dehnen, Dehnen, Diemand, Dolag, Dubinski, Dubinski, Ebisuzaki, Efstathiou, Efstathiou, El-Zant, Evrard, Evrard, Gingold, Gingold, Greengard, Gurbatov, Hamilton, Heitmann, Heitmann, Hernquist, Hernquist, Hernquist, Hernquist, Hockney, Hui, J. S. Bagla, Jain, Jernigan, Joyce, Kanekar, Kawai, Khandai, Klypin, Knebe, Kravtsov, Kuhlman, Little, Lucy, Ma, Macfarland, Makino, Makino, Makino, Makino, Makino, Matarrese, Melott, Merritt, Merz, Miller, Monaghan, Monaghan, Nishikanta Khandai, Nityananda, O'Shea, Padmanabhan, Padmanabhan, Padmanabhan, Peacock, Peacock, Peacock, Peebles, Peebles, Percival, Power, Prasad, Price, Romeo, Sahni, Salmon, Smith, Spergel, Splinter, Springel, Springel, Springel, Springel, Suisalu, Thacker, Theuns, Thiébaut, Wadsley, Xu, Yoshikawa, Zel'Dovich   +113 more
core   +3 more sources

Shuffled Complex-Self Adaptive Hybrid EvoLution (SC-SAHEL) optimization framework [PDF]

, 2018
Simplicity and flexibility of meta-heuristic optimization algorithms have attracted lots of attention in the field of optimization. Different optimization methods, however, hold algorithm-specific strengths and limitations, and selecting the best ...
AghaKouchak, A, Duan, Q, Hsu, KL, Lei, X, Rahnamay Naeini, M, Sadegh, M, Sorooshian, S, Yang, T   +7 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Testing for adaptive evolution of the female reproductive protein ZPC in mammals, birds and fishes reveals problems with the M7-M8 likelihood ratio test

BMC Evolutionary Biology, 2005
Background Adaptive evolution appears to be a common feature of reproductive proteins across a very wide range of organisms. A promising way of addressing the evolutionary forces responsible for this general phenomenon is to test for adaptive evolution ...
Berlin Sofia, Smith Nick GC
doaj   +1 more source

Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires

, 2017
The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in ...
Afzal, Ahmed, Albert, Amanna, Andrews, Angermueller, Apeltsin, Arden, Atchley, Avnir, Barabási, Barak, Bashford-Rogers, Bastian, Baum, Becattini, Ben-Hamo, Berger, Betz, Boc, Bolen, Bolkhovskaya, Bolotin, Bouckaert, Boyd, Boyd, Breden, Brown, Burnet, Bürckert, Calis, Castro, Chang, Chao, Chen, Ching, Cobey, Collins, Corcoran, Covacu, Csardi, Cui, Dash, de Bourcy, DeKosky, DeKosky, DeWitt, Dziubianau, Elhanati, Elhanati, Elhanati, Ellebedy, Emerson, Felsenstein, Friedensohn, Gadala-Maria, Galson, Galson, Geering, Georgiou, Ghraichy, Giribet, Giudicelli, Glanville, Glanville, Glanville, Good, Granato, Greiff, Greiff, Greiff, Greiff, Greiff, Grigaityte, Guindon, Gupta, Gupta, Hagberg, Halliley, Hammarlund, Heather, Hershberg, Hochreiter, Hoehn, Hoehn, Hoehn, Horns, Howie, Iversen, Jackson, Janeway, Jiang, Johnston, Jost, Jurtz, Kaplinsky, Kaplinsky, Kendall, Khavrutskii, Kidd, Kidd, Kidera, Kirik, Konishi, Kumar, Landsverk, Larkin, Lavinder, Laydon, Laydon, Lee, Lee, Lewitus, Li, Lindeman, Lindner, Liu, Love, Lozupone, Madi, Madi, Malissen, Mamoshina, Mangul, Manz, Martin, Meng, Miho, Mora, Morisita, Murugan, Nazarov, Nouri, Oakes, Ostmeyer, Paradis, Parameswaran, Parola, Pinheiro, Pollok, Ralph, Ravn, Reddy, Rempala, Rempala, Revell, Rizzetto, Robinson, Ronquist, Roybal, Rubelt, Rubelt, Safonova, Schliep, Schramm, Schwab, Shannon, Sheng, Sheng, Shlemov, Shugay, Shugay, Shugay, Snir, Snir, Stamatakis, Stern, Strauli, Stubbington, Stubbington, Sun, Sun Cinelli, Swofford, Thomas, Tickotsky, Tonegawa, Torkamani, Trepel, VanDuijn, Venturi, Venturi, Vieira, Vita, Wang, Wardemann, Warren, Watson, Watson, Watson, Weinstein, Wine, Wine, Wu, Yaari, Yaari, Yang, Yeap, Yermanos, Yokota, Yu, Zhu   +200 more
core   +1 more source