Results 81 to 90 of about 1,011,945 (297)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Large-scale geographic patterns and environmental and anthropogenic drivers of wetland plant diversity in the Qinghai-Tibet Plateau

BMC Ecology and Evolution
Background The geographic patterns of plant diversity in the Qinghai-Tibet Plateau (QTP) have been widely studied, but few studies have focused on wetland plants. This study quantified the geographic patterns of wetland plant diversity in the QTP through
Yigang Li, Fan Liu, Yadong Zhou, Xing Liu, Qingfeng Wang   +4 more
doaj   +1 more source

Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]

, 2013
John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D, Gong, Lizhi Ian, Suchard, Marc A   +2 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Long-Term Monitoring Reveals Changes in the Small Mammal Community Composition and Co-Occurrence Patterns in the Diannan Area of Yunnan, China

Biology
Long-term monitoring of small mammal communities provides critical insights into biodiversity conservation by detecting ecosystem degradation and quantifying anthropogenic impacts.
Jinyu Yang, Ting Jia, Wanlong Zhu, Xiaomi Yang   +3 more
doaj   +1 more source

An Adaptive Quantum-inspired Differential Evolution Algorithm for 0-1 Knapsack Problem

, 2010
Differential evolution (DE) is a population based evolutionary algorithm widely used for solving multidimensional global optimization problems over continuous spaces. However, the design of its operators makes it unsuitable for many real-life constrained
Hota, Ashish Ranjan, Pat, Ankit
core   +1 more source

Emergent adaptive behaviour of GRN-controlled simulated robots in a changing environment [PDF]

, 2016
We developed a bio-inspired robot controller combining an artificial genome with an agent-based control system. The genome encodes a gene regulatory network (GRN) that is switched on by environmental cues and, following the rules of transcriptional ...
Marchal, Kathleen, Storme, Veronique, Van de Peer, Yves, Yao, Yao   +3 more
core   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Equipped for Migrations Across High Latitude Regions? Reduced Spur Length and Outcrossing Rate in a Biennial Halenia elliptica (Gentianaceae) With Mixed Mating System Along a Latitude Gradient

Frontiers in Genetics, 2018
Halenia (Gentianaceae) originated from the mountain regions of East Asia, and diversified in America following long migrations via Beringia. While Halenia elliptica, one species of the genus in China, migrated toward high latitudes in China.
Ming-Liu Yang, Lin-Lin Wang, Guo-Peng Zhang, Li-Hua Meng, Yong-Ping Yang, Yong-Ping Yang, Yuan-Wen Duan, Yuan-Wen Duan   +7 more
doaj   +1 more source