Results 81 to 90 of about 277,643 (313)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Towards generic adaptive systems : analysis of a case study [PDF]
, 2002 This paper analyses one of the most well-known general purpose adaptive hypermedia systems, AHA!, and, based on this analysis, make some general observations about adaptive hypermedia systems and some improvement suggestions for the AHA! system.
Cristea, A.I. +7 more
core +1 more source
EnzyHTP Computational Directed Evolution with Adaptive Resource Allocation
, 2023 Directed evolution facilitates enzyme engineering via iterative rounds of mutagenesis. Despite the wide applications of high-throughput screening, building “smart libraries” to effectively identify beneficial variants remains a major challenge in the ...
Zhongyue, Yang +2 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Frontiers in Genetics, 2018 Halenia (Gentianaceae) originated from the mountain regions of East Asia, and diversified in America following long migrations via Beringia. While Halenia elliptica, one species of the genus in China, migrated toward high latitudes in China.
Ming-Liu Yang +7 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Evolutionary branching under multi-dimensional evolutionary constraints.
, 2016 The fitness of an existing phenotype and of a potential mutant should generally depend on the frequencies of other existing phenotypes. Adaptive evolution driven by such frequency-dependent fitness functions can be analyzed effectively using adaptive ...
ITO, Hiroshi, SASAKI, Akira
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A comparative study of adaptive mutation operators for metaheuristics [PDF]
, 2009 Genetic algorithms (GAs) are a class of stochastic optimization methods inspired by the principles of natural evolution. Adaptation of strategy parameters and genetic operators has become an important and promising research area in GAs.
Yang, S +5 more
core
Why rapid, adaptive evolution matters for community dynamics
, 2014 Evolution on contemporary timescales has recently been recognized as an important driver for ecological change. It is now well established that evolutionary change can affect the interactions between species within a few generations and that ecological ...
Becks, Lutz +15 more
core +1 more source