Results 1 to 10 of about 6,029 (70)

Generation of induced pluripotent stem cell line (TMOi001-A-11) carrying a homozygous deletion in the synemin gene using CRISPR/Cas9

Stem Cell Research, 2023
A number of genetic variants in the SYNM gene encoding for the intermediate filament synemin have been reported in patients with cardiomyopathies, skeletal myopathies, cancer and certain neurodegenerative disorders.
Caterina Gargano, Jean-Sébastien Vartanian-Grimaldi, Yeranuhi Hovhannisyan, Pierre Joanne, Onnik Agbulut, Zhenlin Li, Ara Parlakian, Jean-François Decaux   +7 more
doaj   +1 more source

Computational Probing the Methylation Sites Related to EGFR Inhibitor-Responsive Genes

Biomolecules, 2021
The emergence of drug resistance is one of the main obstacles to the treatment of lung cancer patients with EGFR inhibitors. Here, to further understand the mechanism of EGFR inhibitors in lung cancer and offer novel therapeutic targets for anti-EGFR ...
Rui Yuan, Shilong Chen, Yongcui Wang
doaj   +1 more source

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

Cells, 2021
Heat shock proteins (Hsps) represent the most evolutionarily ancient, conserved, and universal system for protecting cells and the whole body from various types of stress.
Olga G. Zatsepina, Michael B. Evgen’ev, David G. Garbuz   +2 more
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Cyto- and bio-compatibility assessment of plasma-treated polyvinylidene fluoride scaffolds for cardiac tissue engineering

Frontiers in Bioengineering and Biotechnology, 2022
As part of applications dealing with cardiovascular tissue engineering, drop-cast polyvinylidene fluoride (PVDF) scaffolds have been treated by cold plasma to enhance their adherence to cardiac cells.
Maria Kitsara, Gaëlle Revet, Jean-Sébastien Vartanian-Grimaldi, Alexandre Simon, Mathilde Minguy, Antoine Miche, Vincent Humblot, Vincent Humblot, Thierry Dufour, Onnik Agbulut   +9 more
doaj   +1 more source

Absence of Desmin Results in Impaired Adaptive Response to Mechanical Overloading of Skeletal Muscle

Frontiers in Cell and Developmental Biology, 2021
Background: Desmin is a muscle-specific protein belonging to the intermediate filament family. Desmin mutations are linked to skeletal muscle defects, including inherited myopathies with severe clinical manifestations.
Pierre Joanne, Yeranuhi Hovhannisyan, Maximilien Bencze, Marie-Thérèse Daher, Ara Parlakian, Geraldine Toutirais, Jacqueline Gao-Li, Alain Lilienbaum, Zhenlin Li, Ekaterini Kordeli, Arnaud Ferry, Arnaud Ferry, Onnik Agbulut   +12 more
doaj   +1 more source

Evaluación de la estructura espacial de Triatoma maculata del centro-occidente de Venezuela y su viabilidad alimentado con sangre humana en condiciones de laboratorio

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. Dado el reiterado hallazgo de adultos y formas inmaduras de Triatoma maculata capturados en domicilios y peridomicilios en la localidad de Xaguas (Venezuela), se analizó la viabilidad de una colonia de laboratorio de esta especie alimentada
Keila Torres, Francys Avendaño-Rangel, Eliécer Lizano, María Rojas, Claudina Rodríguez-Bonfante, Rafael Bonfante-Cabarcas, Elis Aldana   +6 more
doaj   +1 more source

Serum Response Factor in muscle tissues: from development to ageing

European Journal of Translational Myology, 2016
Skeletal, cardiac and smooth muscle cells share various common characteristic features. During development the embryonic mesodermal layer contribute at different proportions to the formation of these tissues.
Dario Coletti, Nissrine Daou, Medhi Hassani, Zhenlin Li, Ara Parlakian   +4 more
doaj   +1 more source

What are the effects of climate variability and change on ungulate life-histories, population dynamics, and migration in North America? A systematic map protocol

Environmental Evidence, 2020
Background Climate is an important driver of ungulate life-histories, population dynamics, and migratory behaviors, and can affect the growth, development, fecundity, dispersal, and demographic trends of populations.
Katherine C. Malpeli, Sarah R. Weiskopf, Laura Thompson, Amanda R. Hardy   +3 more
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Climate change and the global redistribution of biodiversity: substantial variation in empirical support for expected range shifts

Environmental Evidence, 2023
Background Among the most widely predicted climate change-related impacts to biodiversity are geographic range shifts, whereby species shift their spatial distribution to track their climate niches.
Madeleine A. Rubenstein, Sarah R. Weiskopf, Romain Bertrand, Shawn L. Carter, Lise Comte, Mitchell J. Eaton, Ciara G. Johnson, Jonathan Lenoir, Abigail J. Lynch, Brian W. Miller, Toni Lyn Morelli, Mari Angel Rodriguez, Adam Terando, Laura M. Thompson   +13 more
doaj   +1 more source

Slug, a Cancer‐Related Transcription Factor, is Involved in Vascular Smooth Muscle Cell Transdifferentiation Induced by Platelet‐Derived Growth Factor‐BB During Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Heart attacks and stroke often result from occlusive thrombi following the rupture of vulnerable atherosclerotic plaques. Vascular smooth muscle cells (VSMCs) play a pivotal role in plaque vulnerability because of their switch towards a ...
Nahéma Ledard, Alexandrine Liboz, Bertrand Blondeau, Mégane Babiak, Célia Moulin, Benjamin Vallin, Isabelle Guillas, Véronique Mateo, Claire Jumeau, Karl Blirando, Olivier Meilhac, Isabelle Limon, Martine Glorian   +12 more
doaj   +1 more source