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Distinguishing Biological Trends from Adaptation

Philosophy, Theory, and Practice in Biology, 2022
Models of evolution commonly decompose change into deterministic and stochastic components. Different models, however, produce different concepts of signal and noise.
Lucas John Mix
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Generation of induced pluripotent stem cell line (TMOi001-A-11) carrying a homozygous deletion in the synemin gene using CRISPR/Cas9

Stem Cell Research, 2023
A number of genetic variants in the SYNM gene encoding for the intermediate filament synemin have been reported in patients with cardiomyopathies, skeletal myopathies, cancer and certain neurodegenerative disorders.
Caterina Gargano, Jean-Sébastien Vartanian-Grimaldi, Yeranuhi Hovhannisyan, Pierre Joanne, Onnik Agbulut, Zhenlin Li, Ara Parlakian, Jean-François Decaux   +7 more
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Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

Cells, 2021
Heat shock proteins (Hsps) represent the most evolutionarily ancient, conserved, and universal system for protecting cells and the whole body from various types of stress.
Olga G. Zatsepina, Michael B. Evgen’ev, David G. Garbuz   +2 more
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Computational Probing the Methylation Sites Related to EGFR Inhibitor-Responsive Genes

Biomolecules, 2021
The emergence of drug resistance is one of the main obstacles to the treatment of lung cancer patients with EGFR inhibitors. Here, to further understand the mechanism of EGFR inhibitors in lung cancer and offer novel therapeutic targets for anti-EGFR ...
Rui Yuan, Shilong Chen, Yongcui Wang
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Modeling adaptive biological systems [PDF]

Biosystems, 1989
During the evolution of many systems found in nature, both the system composition and the interactions between components will vary. Equating the dimension with the number of different components, a system which adds or deletes components belongs to a class of dynamical systems with a finite dimensional phase space of variable dimension. We present two
Bagley, R. J., Farmer, J. D., Kauffman, S. A., Packard, N. H., Perelson, Alan S., Stadnyk, I. M.   +5 more
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Cyto- and bio-compatibility assessment of plasma-treated polyvinylidene fluoride scaffolds for cardiac tissue engineering

Frontiers in Bioengineering and Biotechnology, 2022
As part of applications dealing with cardiovascular tissue engineering, drop-cast polyvinylidene fluoride (PVDF) scaffolds have been treated by cold plasma to enhance their adherence to cardiac cells.
Maria Kitsara, Gaëlle Revet, Jean-Sébastien Vartanian-Grimaldi, Alexandre Simon, Mathilde Minguy, Antoine Miche, Vincent Humblot, Vincent Humblot, Thierry Dufour, Onnik Agbulut   +9 more
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Absence of Desmin Results in Impaired Adaptive Response to Mechanical Overloading of Skeletal Muscle

Frontiers in Cell and Developmental Biology, 2021
Background: Desmin is a muscle-specific protein belonging to the intermediate filament family. Desmin mutations are linked to skeletal muscle defects, including inherited myopathies with severe clinical manifestations.
Pierre Joanne, Yeranuhi Hovhannisyan, Maximilien Bencze, Marie-Thérèse Daher, Ara Parlakian, Geraldine Toutirais, Jacqueline Gao-Li, Alain Lilienbaum, Zhenlin Li, Ekaterini Kordeli, Arnaud Ferry, Arnaud Ferry, Onnik Agbulut   +12 more
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What are the effects of climate variability and change on ungulate life-histories, population dynamics, and migration in North America? A systematic map protocol

Environmental Evidence, 2020
Background Climate is an important driver of ungulate life-histories, population dynamics, and migratory behaviors, and can affect the growth, development, fecundity, dispersal, and demographic trends of populations.
Katherine C. Malpeli, Sarah R. Weiskopf, Laura Thompson, Amanda R. Hardy   +3 more
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Evaluación de la estructura espacial de Triatoma maculata del centro-occidente de Venezuela y su viabilidad alimentado con sangre humana en condiciones de laboratorio

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. Dado el reiterado hallazgo de adultos y formas inmaduras de Triatoma maculata capturados en domicilios y peridomicilios en la localidad de Xaguas (Venezuela), se analizó la viabilidad de una colonia de laboratorio de esta especie alimentada
Keila Torres, Francys Avendaño-Rangel, Eliécer Lizano, María Rojas, Claudina Rodríguez-Bonfante, Rafael Bonfante-Cabarcas, Elis Aldana   +6 more
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Serum Response Factor in muscle tissues: from development to ageing

European Journal of Translational Myology, 2016
Skeletal, cardiac and smooth muscle cells share various common characteristic features. During development the embryonic mesodermal layer contribute at different proportions to the formation of these tissues.
Dario Coletti, Nissrine Daou, Medhi Hassani, Zhenlin Li, Ara Parlakian   +4 more
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