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Symmetry Invariance for Adapting Biological Systems [PDF]

SIAM Journal on Applied Dynamical Systems, 2011
We study in this paper certain properties of the responses of dynamical systems to external inputs. The motivation arises from molecular systems biology. and, in particular, the recent discovery of an important transient property, related to Weber's law in psychophysics: "fold-change detection" in adapting systems, the property that scale uncertainty ...
Shoval, Oren, Alon, Uri, Sontag, Eduardo
openaire   +2 more sources

What is a hologenomic adaptation? Emergent individuality and inter-identity in multispecies systems [PDF]

, 2020
Contemporary biological research has suggested that some host–microbiome multispecies systems (referred to as “holobionts”) can in certain circumstances evolve as unique biological individual, thus being a unit of selection in evolution.
Arnellos, Austin, Austin, Austin, Bedau, Bigelow, Boogerd, Boorse, Booth, Bordenstein, Bouchard, Bouchard, Bouchard, Bouchard, Bouchard, Bourrat, Brooks, Brucker, Brucker, Brucker, Burke, Campbell, Canciani, Catania, Chalmers, Chandler, Chiu, Chiu, Chong, Clarke, Clarke, Dethlefsen, DiFrisco, Doolittle, Douglas, Dupré, Dupré, Dupré, Dupré, Díaz, Gilbert, Gilbert, Gilbert, Gilbert, Gilbert, Gilbert, Godfrey-Smith, Godfrey-Smith, Godfrey-Smith, Godfrey-Smith, Godfrey-Smith, Godfrey-Smith, Grant, Grant, Green, Guay, Hester, Humphreys, Hurst, Hölldobler, Kim, Kim, Kitcher, Koga, Kushmaro, Laplane, Lemanceau, Lewontin, Lidgard, Lloyd, Lloyd, Lloyd, Lloyd, Lloyd, Louca, Lowe, Maynard-Smith, Mayr, Mazel, McCall, McCall, Mendoza, Miller, Miller, Millikan, Mitchell, Moran, Moreno, Mossio, Mossio, Mumford, Nicholson, Nicholson, Nicholson, Okasha, O’Connor, O’Connor, Pepper, Pradeu, Pradeu, Pradeu, Pradeu, Queller, Reshef, Rosenberg, Rosenberg, Rosenberg, Roughgarden, Rudman, Sapp, Sartenaer, Silberstein, Skillings, Sober, Sober, Sober, Stencel, Stencel, Stencel, Suárez, Suárez, Suárez, Suárez, Taxis, Theis, Thompson, Triviño, Triviño, Uhr, van Gulick, Walsh, Waters, Wiggins, Williams, Wilson, Wilson, Wilson, Wilson, Wright, Zilber-Rosenberg   +139 more
core   +2 more sources

Vulnerability of Estuarine Systems in the Contiguous United States to Water Quality Change Under Future Climate and Land‐Use

Earth's Future, 2023
Changes in climate and land‐use and land‐cover (LULC) are expected to influence surface water runoff and nutrient characteristics of estuarine watersheds, but the extent to which estuaries are vulnerable to altered nutrient loading under future ...
L. R. Montefiore, N. G. Nelson, M. D. Staudinger, A. Terando   +3 more
doaj   +1 more source

Evolutionary adaptability of biological macromolecules [PDF]

Journal of Molecular Evolution, 1977
The degree of gradualism with which tertiary structure and function of protein changes with stepwise changes in primary structure (assumed to be influenced by redundancy of weak bonding) is both a precondition for and consequence of evolution. The resulting selection for degree of gradualism has implications for a number of structural and functional ...
openaire   +3 more sources

Biological clockwork underlying adaptive rhythmic movements [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Animals can adapt the frequency and shape of their oscillatory body movements during locomotion in response to changes in the environment. Although central pattern generators (CPGs) are known to be the basic neuronal circuits responsible for generation of rhythmic movements, no conclusive evidence has so far been found to ...
Chen, Jun, Friesen, W, Iwasaki, Tetsuya
openaire   +6 more sources

Predicting cortical bone adaptation to axial loading in the mouse tibia [PDF]

, 2015
The development of predictive mathematical models can contribute to a deeper understanding of the specific stages of bone mechanobiology and the process by which bone adapts to mechanical forces.
A. A. Pitsillides, A. F. Pereira, B. Javaheri, Cavanagh PR, Cowin SC, Frost HM, Phillips ATM, Robling AG, S. J. Shefelbine, Steck R   +9 more
core   +3 more sources

Tradeoffs in adapting biological systems

European Journal of Control, 2016
Biological systems must sense and adapt to changes in their environment. Molecular networks capable of such adaptation belong to two well-known classes, feed-forward and feedback structures, but the fundamental limitations and tradeoffs of these two classes remain unknown.
Bhatnagar, Rajat, El-Samad, Hana
openaire   +4 more sources

Rbm24 displays dynamic functions required for myogenic differentiation during muscle regeneration

Scientific Reports, 2021
Skeletal muscle has a remarkable capacity of regeneration after injury, but the regulatory network underlying this repair process remains elusive. RNA-binding proteins play key roles in the post-transcriptional regulation of gene expression and the ...
Raphaëlle Grifone, Audrey Saquet, Manon Desgres, Claudia Sangiorgi, Caterina Gargano, Zhenlin Li, Dario Coletti, De-Li Shi   +7 more
doaj   +1 more source

Computational Prediction of Drug Responses in Cancer Cell Lines From Cancer Omics and Detection of Drug Effectiveness Related Methylation Sites

Frontiers in Genetics, 2020
Accurately predicting the response of a cancer patient to a therapeutic agent remains an important challenge in precision medicine. With the rise of data science, researchers have applied computational models to study the drug inhibition effects on ...
Rui Yuan, Rui Yuan, Shilong Chen, Shilong Chen, Yongcui Wang, Yongcui Wang   +5 more
doaj   +1 more source

Resilience, Regime Shifts, and Guided Transition under Climate Change: Examining the Practical Difficulties of Managing Continually Changing Systems

Ecology and Society, 2013
Managing terrestrial systems has become increasingly difficult under climate change as unidirectional shifts in climate conditions challenge the resilience of ecosystems to maintain their compositional structure and function.
Brenda B. Lin, Brian Petersen
doaj   +1 more source