Results 141 to 150 of about 1,014,656 (349)

Peer Review #1 of "Comparative analysis of chloroplast genomes for five Dicliptera species (Acanthaceae): molecular structure, phylogenetic relationships, and adaptive evolution (v0.1)"

, 2020

openalex   +1 more source

A neglected conceptual problem regarding phenotypic plasticity's role in adaptive evolution: The importance of genetic covariance and social drive [PDF]

, 2021
Nathan W. Bailey, Camille Desjonquères, Ana Drago, Jack G. Rayner, Samantha L. Sturiale, Xiao Zhang   +5 more
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Evolution and Adaptation

, 1903
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +5 more sources

Nonlinear transformation of probabilities by large language models

Computers in Human Behavior: Artificial Humans
Large Language Models (LLMs) such as ChatGPT and Claude demonstrate impressive abilities to generate meaningful text and mimic human-like responses. While they undoubtedly can boost human performance, there is also the risk that uninstructed users rely ...
Arend Hintze, Charu Bisht, Jory Schossau, Ralph Hertwig   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome

Nature Communications
Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time.
Shixuan Liu, Camille Ezran, Michael F. Z. Wang, Zhengda Li, Kyle Awayan, The Tabula Microcebus Consortium, Jonathan Z. Long, Iwijn De Vlaminck, Sheng Wang, Jacques Epelbaum, Christin S. Kuo, Jérémy Terrien, Mark A. Krasnow, James E. Ferrell   +13 more
doaj   +1 more source

Supporting Computational Data for publication: "Engineering Improved Ethylene Production: Leveraging Systems Biology and Adaptive Laboratory Evolution"

, 2021
Christof Jaeger
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The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source