Results 131 to 140 of about 1,011,945 (297)

Evolution and Adaptation

, 1903
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +5 more sources

Nonlinear transformation of probabilities by large language models

Computers in Human Behavior: Artificial Humans
Large Language Models (LLMs) such as ChatGPT and Claude demonstrate impressive abilities to generate meaningful text and mimic human-like responses. While they undoubtedly can boost human performance, there is also the risk that uninstructed users rely ...
Arend Hintze, Charu Bisht, Jory Schossau, Ralph Hertwig   +3 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome

Nature Communications
Hormones mediate long-range cell communication and play vital roles in physiology, metabolism, and health. Traditionally, endocrinologists have focused on one hormone or organ system at a time.
Shixuan Liu, Camille Ezran, Michael F. Z. Wang, Zhengda Li, Kyle Awayan, The Tabula Microcebus Consortium, Jonathan Z. Long, Iwijn De Vlaminck, Sheng Wang, Jacques Epelbaum, Christin S. Kuo, Jérémy Terrien, Mark A. Krasnow, James E. Ferrell   +13 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Phylogeny, adaptive evolution, and taxonomy of Acronema (Apiaceae): evidence from plastid phylogenomics and morphological data

Frontiers in Plant Science
IntroductionThe genus Acronema, belonging to Apiaceae, includes approximately 25 species distributed in the high-altitude Sino-Himalayan region from E Nepal to SW China. This genus is a taxonomically complex genus with often indistinct species boundaries
Lian Chen, Bo-Ni Song, Lei Yang, Yuan Wang, Yun-Yi Wang, Xueyimu Aou, Xing-Jin He, Song-Dong Zhou   +7 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Comprehensive Analysis of the Multiple AP2/ERF Regulatory Network Unveils Putative Components of the Fatty Acid Pathway for Environmental Adaptation

Agronomy
Environmental stresses significantly influence crop growth and productivity, acting as powerful selective pressures in plant evolution. The AP2/ERF superfamily is crucial for plant development and stress responses, orchestrating key regulatory pathways ...
Junjie Deng, Ming Yang, Heng Liang, Daojun Zheng, Guangshun Zhu, Zhenpei Ye, Xinjie Lai, Moyang Liu   +7 more
doaj   +1 more source