Results 121 to 130 of about 277,643 (313)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Eemian palaeogenetics demonstrates loss of diversity in modern fallow deer (Dama dama)

iScience
Summary: The European fallow deer (Dama dama) is a widely distributed cervid that has experienced extensive human management since the Neolithic. Although several studies have examined relationships among present-day and Holocene populations, molecular ...
Alberto Rocha-Méndez, Patrick Arnold, Lutz Kindler, Sabine Gaudzinski-Windheuser, Wil Roebroeks, Fulco Scherjon, Michael Hofreiter   +6 more
doaj   +1 more source

Bridgehead Effects and Role of Adaptive Evolution in Invasive Populations

, 2018
Biological invasions are a major threat to biodiversity, agriculture, and human health. Invasive populations can be the source of additional new introductions, leading to a self-accelerating process whereby invasion begets invasion.
Keller, L., Cleo Bertelsmeier, Laurent Keller, Bertelsmeier, C.   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Role of immigrant males and muzzle contacts in the uptake of a novel food by wild vervet monkeys

eLife
The entry into and uptake of information in social groups is critical for behavioral adaptation by long-lived species in rapidly changing environments.
Pooja Dongre, Gaëlle Lanté, Mathieu Cantat, Charlotte Canteloup, Erica van de Waal   +4 more
doaj   +1 more source

Manipulation of trait expression and pollination regime reveals the adaptive significance of spur length

, 2020
Understanding the mechanisms of adaptive population differentiation requires that both the functional and adaptive significance of divergent traits are characterized in contrasting environments.
Trunschke, Judith, Ågren, Jon,, Ågren, Jon, Trunschke, Judith,, Sletvold, Nina,, Sletvold, Nina   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Behavioural evolution: Darwin's theory and adaptive behaviour

, 2016
When thinking about Darwin's theory of evolution amazing physical adaptations to the challenges of survival come to mind. But it's not just the body that has evolved to fit, behaviour and cognitive abilities are as essential to survival as bones ...
Osthaus, B., Hocking, I.
core