Results 81 to 90 of about 181,123 (313)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
An Enhanced Adaptive Set-Membership Filter for Nonlinear Ellipsoidal Estimation
, 2007 The extended set-membership filter (ESMF) for nonlinear ellipsoidal estimation suffers from numerical instability, computation complexity, as well as the difficulty in filter parameter selection.
Liu GJ(刘光军) +2 more
core +1 more source
Active Optical Lattice Filters
EURASIP Journal on Advances in Signal Processing, 2005 Optical lattice filter structures including gains are introduced and analyzed. The photonic realization of the active, adaptive lattice filter is described.
Gary Evans +6 more
doaj +1 more source
A Subband Adaptive Equalization Structure
, 1999 The potential presence of fractional delays, non-minimum phase parts, and a colouring of the channel output can require adaptive equalizers to adapt very long impulse responses.
Weiss, Stephan +6 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
An adaptive hybrid filter for practical WiFi-based positioning systems
ICT Express, 2015 This paper proposes an adaptive hybrid filter for WiFi-based indoor positioning systems. The hybrid filter adopts the notion of particle filters within the prediction framework of the basic Kalman filter.
Namjun Park, Sukhoon Jung, Dongsoo Han
doaj +1 more source
Fast Implementation of Oversampled Modulated Filter Banks
, 2000 This paper presents an efficient implementation of oversampled filter banks derived from a prototype filter by modulation. Via a polyphase analysis, redundancies in the filter operations are removed.
Weiss, Stephan +5 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source