Results 71 to 80 of about 181,123 (313)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Kalman interpolation filter for channel estimation of LTE downlink in high-mobility environments [PDF]

, 2012
The estimation of fast-fading LTE downlink channels in high-speed applications of LTE advanced is investigated in this article. In order to adequately track the fast time-varying channel response, an adaptive channel estimation and interpolation ...
Dai, Xuewu, Zhang, W, Xuewu Dai, Dai, X, Yang, Y, Mitchell, JE, Yang, Yang, John E Mitchell, Xu, Jing, Jing Xu, Mitchell, John, Xu, J, Zhang, Wuxiong, Yang Yang, Wuxiong Zhang   +14 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Nonlinear Effects of the LMS Adaptive Predictor for Chirped Input Signals

EURASIP Journal on Advances in Signal Processing, 2002
This paper investigates the nonlinear effects of the Least Mean Square (LMS) adaptive predictor. Traditional analysis of the adaptive filter ignores the statistical dependence among successive tap-input vectors and bounds the performance of the adaptive
Han Jun, Zeidler James R, Ku Walter H
doaj   +1 more source

An Integrated Adaptive Kalman Filter for High-Speed UAVs

Applied Sciences, 2019
In order to solve the problems of filtering divergence and low accuracy in Kalman filter (KF) applications in a high-speed unmanned aerial vehicle (UAV), this paper proposed a new method of integrated robust adaptive Kalman filter: strong adaptive Kalman
Tiantian Huang, Hui Jiang, Zhuoyang Zou, Lingyun Ye, Kaichen Song   +4 more
doaj   +1 more source

Investigation of Bispectral Index filtering and improvement using wavelet transform adaptive filter [PDF]

, 2010
Electroencephalogram (EEG) signals are often contaminated with artifacts such as electromyography (EMG), eye blink and eye ball movement. These contaminated EEG signals may give incorrect values of Bispectral Index.
Wen, Peng, Mario Elvis Palendeng, Steven Goh, Palendeng, Mario Elvis, Peng Wen, Goh, Steven   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Digital IIR filter design using particle swarm optimisation [PDF]

, 2010
Adaptive infinite-impulse-response (IIR) filtering provides a powerful approach for solving a variety of practical signal processing problems. Because the error surface of IIR filters is typically multimodal, global optimisation techniques are generally ...
Chen, Sheng, Luk, Bing L.
core  

Observations on adaptive vector filters for noise reduction in color images

, 2004
In a series of papers, Plataniotis et al. proposed a number of filters for noise reduction in color images where the noise type is unknown. In this letter, those filters with a unified notation are summarized, and it is shown that they are essentially ...
Cree, Michael J.
core   +1 more source