Results 211 to 220 of about 5,026,401 (367)

Targeting innate and adaptive immunity to suppress lung cancer metastasis. [PDF]

Front Immunol
Qin R.
europepmc   +1 more source

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

Advanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham, Jose Gabriel Castro, Lisette C. Werba, Joseph Amitrano, Luke Fardone, Kevin P. Francis, Anand Ramamurthi, Michael J. Layden, Helen O. McCarthy, Tomas Gonzalez‐Fernandez   +9 more
wiley   +1 more source

Emerging roles for innate and adaptive immunity in tauopathies. [PDF]

Cell Rep
Johnson AM, Lukens JR.
europepmc   +1 more source

Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy

Jing Liu, Xiaomin Jiang, Youyou Li, Kaiting Yang, Ralph R. Weichselbaum, Wenbin Lin   +5 more
openalex   +2 more sources

Spatial transcriptomics reveals distinct inflammatory and adaptive immune properties of rheumatoid arthritis synovial fibroblasts [PDF]

Camilla Ribeiro Lima Machado, Mina Yao, David L. Boyle, Robert J. Benschop, James Parker, Wei Wang, Gary S. Firestein   +6 more
openalex   +1 more source

Plasma‐Treated Hydrogel for Combined RONS and Chemotherapy Delivery: A Proof‐of‐Concept In Ovo

Advanced Functional Materials, EarlyView.
This study explores plasma‐treated hydrogels (PTH) as a new way to deliver both reactive oxygen and nitrogen species and chemotherapy (Doxorubicin) directly to tumors. In ovo tests show effects after a single dose, especially in osteosarcoma tumors. Tumor weight decrease, and a resistance‐related protein is reduced.
Milica Živanić, Albert Espona‐Noguera, Angela Privat Maldonado, Patrik Matušů, Francesco Tampieri, Maria‐Pau Ginebra, Abraham Lin, Evelien Smits, Annemie Bogaerts, Cristina Canal   +9 more
wiley   +1 more source

Targeting the role played by microbiota and adaptive immunity within autoimmune disease complexity. [PDF]

Front Immunol
Bredberg A, Nermo KR, Henriksson G.
europepmc   +1 more source

Impacts of Plcg2 variants on adaptive immune cells in the late-onset Alzheimer’s disease (LOAD2) mouse model 9265 [PDF]

Jaid Perez, Yangming Xiao, Samantha Kahealani Archuleta, Eduardo Kuri Gutierrez, Juliet Lynn Marie Garcia-Rogers, Sabrina Smith, Sarah A. Wedemeyer, Tariq Elhashim, Sarah C Hopp, Juan Pablo Palavicini, Ann Griffith   +10 more
openalex   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source

Adaptive immunity in the pathogenesis and treatments of Parkinson's disease. [PDF]

NeuroImmune Pharm Ther
Du X, Akter S, Oludipe DB, Sil S, Zhang C, Gendelman HE, Mosley RL.   +6 more
europepmc   +1 more source