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THE EVOLUTION OF ADAPTIVE IMMUNITY
Annual Review of Immunology, 2006Approximately 500 mya two types of recombinatorial adaptive immune systems appeared in vertebrates. Jawed vertebrates generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish assemble their variable lymphocyte receptors through recombinatorial usage of ...
Zeev, Pancer, Max D, Cooper
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Evolution of adaptive immunity
Biology Bulletin, 2009The current state of the problem of emergence and evolution of adaptive immunity in different taxonomic groups of animals is analyzed. Special attention is given to the emergence and phylogenetic development of the lymphocyte, the key component of immune response, as well as to the evolutionary development of T- and B-cell immune systems, adaptive ...
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Temperature and adaptive immunity
2018The adaptive immune response has evolved over hundreds of millions of years to have exquisitely specific and durable mechanisms to eliminate pathogenic threats wherever they may occur in the body. Temperature has long been known to influence the response to infections, injuries, and even cancer; however, the mechanistic basis of these effects has only ...
Michelle M, Appenheimer, Sharon S, Evans
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The Adaptation Model of Immunity
Immunotherapy, 2013Although 'self-nonself' and 'danger' theories have improved our understanding of the immune system, successful immunotherapy of cancer and many autoimmune diseases still remain far from reach. This indicates that our knowledge of how the immune system decides to respond effectively or ineffectively is limited.
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The Evolution of Adaptive Immunity
2012The concept of adaptive immunity suggests de novo generation in each individual of extremely large repertoires of diversified receptors and selective expansion of receptors that match the antigen/pathogen. Accordingly, adaptive immune system is also called "anticipatory".
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T‐cell receptor and B‐cell receptor repertoire profiling in adaptive immunity
Transplant International, 2019B‐cell receptors and T‐cell receptors are the key molecules responsible for specific antigen recognition in adaptive immunity. The huge diversity of immune receptor repertoires constrained their comprehensive studies in the past.
A. Minervina +2 more
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Interleukin-12 and the regulation of innate resistance and adaptive immunity
Nature reviews. Immunology, 2003G. Trinchieri
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Circadian rhythms in adaptive immunity and vaccination
Seminars in Immunopathology, 2021N. Cermakian +3 more
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Immune mechanisms: adaptive immunity
2016The role of adaptive immunity (i.e. the involvement of B and T lymphocytes) in the pathogenesis of axial spondyloarthritis has been investigated in both human disease and relevant animal models. Studies of B cell responses have not generally implicated an autoantibody in the disease, but there are abnormalities of antibody responses, particularly ...
Maxime Breban, Hill Gaston
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MiXCR: software for comprehensive adaptive immunity profiling
Nature Methods, 2015D. A. Bolotin +6 more
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