Results 41 to 50 of about 9,146 (257)
Adaptive Large Neighborhood Search for Multitrip Vehicle Routing with Time Windows [PDF]
Transportation Science, 2019 We consider a multitrip vehicle routing problem with time windows (MTVRPTW), in which each vehicle can perform several trips during its working shift. This problem is especially relevant in the context of city logistics. Heuristic solution methods for multitrip vehicle routing problems often separate routing and assignment phases to create trips and ...
François, Véronique +2 more
openaire +2 more sources
IEEE Access, 2023 The unrelated parallel machine scheduling problem with sequence dependent setup times (UPMSP-SDST) addressed in this study refers to allocating jobs among a given number of machines and determining their processing sequence on each machine, to minimize ...
Bin Ji +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Emergency Relief Material Distribution Path Optimization Under Multiple Constraints
Applied SciencesTo overcome the limitations of traditional methods in emergency response scenarios—such as limited adaptability during the search process and a tendency to fall into local optima, which reduce the overall efficiency of emergency supply distribution—this ...
Haoran He +5 more
doaj +1 more source
IEEE Access, 2021 The Partial Max-SAT (PMSAT) problem is an optimization variant of the well-known Propositional Boolean Satisfiability (SAT) problem. It holds an important place in theory and practice, because a huge number of real-world problems, such as timetabling ...
Haifa Hamad Alkasem +1 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Applied SciencesCompared to fossil fuel-based internal combustion vehicles, electric vehicles with lower local pollution and noise are becoming more and more popular in urban logistic distribution.
Dan Wang, Weibo Zheng, Hong Zhou
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source