Results 41 to 50 of about 10,836,415 (286)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Emergency Relief Material Distribution Path Optimization Under Multiple Constraints
Applied SciencesTo overcome the limitations of traditional methods in emergency response scenarios—such as limited adaptability during the search process and a tendency to fall into local optima, which reduce the overall efficiency of emergency supply distribution—this ...
Haoran He +5 more
doaj +1 more source
A Heuristic Approach for a Real-World Electric Vehicle Routing Problem
Algorithms, 2019 To develop a non-polluting and sustainable city, urban administrators encourage logistics companies to use electric vehicles instead of conventional (i.e., fuel-based) vehicles for transportation services.
Mengting Zhao, Yuwei Lu
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Applied SciencesCompared to fossil fuel-based internal combustion vehicles, electric vehicles with lower local pollution and noise are becoming more and more popular in urban logistic distribution.
Dan Wang, Weibo Zheng, Hong Zhou
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Biomimetics, 2023 Sand cat swarm optimization algorithm (SCSO) keeps a potent and straightforward meta-heuristic algorithm derived from the distant sense of hearing of sand cats, which shows excellent performance in some large-scale optimization problems.
Xing Wang, Qian Liu, Li Zhang
doaj +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Split-merge:using exponential neighborhood search for scheduling a batching machine [PDF]
, 2015 We address the problem of scheduling a single batching machine to minimize the maximum lateness with a constraint restricting the batch size. A solution for this NP-hard problem is defined by a selection of jobs for each batch and an ordering of those ...
Song, Xiang +3 more
core +1 more source
Very Large-Scale Neighborhood Search
, 2021 Very Large-Scale Neighborhood Search is not an algorithm or a class of algorithms, but rather a conceptual framework which can be used for solving combinatorial optimization problems. The approach “concentrates on neighborhood search algorithms where the
Thomas Stützle +5 more
core +1 more source