Results 61 to 70 of about 10,836,415 (286)

eVTOL Route Planning for Urban Low-Altitude Bus Services Considering Dynamic Passenger Load Variations and Battery Safety Constraints

Mathematics
Urban low-altitude bus operations require coordinated eVTOL route decisions under station time windows, dynamic passenger boarding and alighting, load-dependent energy consumption, opportunity charging, and battery safety requirements.
Guohua Wu, Wen Xie, Guangzhi Wang, Fangyu Hong, Fen Xing   +4 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A hybrid adaptive large neighborhood search algorithm for two-echelon electric vehicle routing problem

Scientific Reports
The efficient management of urban logistics is important for smart production and service systems, requiring coordinated optimization and planning for sustainable and responsive operations.
Dian Huang, Hugang Wang, Wenlei Wang, Li Zhang   +3 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Research on Route Optimization of Single-Supply-Point Perishable Goods Multimodal Transport Considering Transportation Vibration Loss

Mathematics
As the market of perishable goods in China continues to expand, reducing quality loss during transportation has become an urgent issue for the industry.
Yang Xu, Mei-Juan Ma, Xin Zhang, Bin Su, Meng Zhang, Qing-E Guo   +5 more
doaj   +1 more source

International Timetabling Competition 2011: An Adaptive Large Neighborhood Search algorithm [PDF]

, 2012
An algorithm based on Adaptive Large Neighborhood Search (ALNS) for solving the generalized High School Timetabling problem in XHSTT-format (Post et al (2012a)) is presented.
Stidsen, Thomas Riis, Sørensen, Matias, Kristiansen, Simon   +2 more
core  

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Reinforced Adaptive Large Neighborhood Search

, 2011
The Large Neighborhood Search metaheuristic for solving Constrained Optimization Problems has been proved to be effective on a wide range of problems.
Deville, Yves, Van Hentenryck, Pascal, Eightth International Workshop on Local Search Techniques in Constraint Satisfaction (LSCS2011), Mairy, Jean-Baptiste   +3 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source