Results 51 to 60 of about 10,453,390 (281)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Large Neighborhood Search for Variants of TSP

, 2007
International audienceTo solve problems with Local Search procedures, neighborhoods have to be defined. During the resolution, a solution is typically replaced by the best solution found in its neighborhood.
Artigues, Christian, Feillet, Dominique, Bontoux, Boris   +2 more
core   +7 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Stochastic Local Search Algorithm for the Partial Max-SAT Problem Based on Adaptive Tuning and Variable Depth Neighborhood Search

IEEE Access, 2021
The Partial Max-SAT (PMSAT) problem is an optimization variant of the well-known Propositional Boolean Satisfiability (SAT) problem. It holds an important place in theory and practice, because a huge number of real-world problems, such as timetabling ...
Haifa Hamad Alkasem, Mohamed El Bachir Menai   +1 more
doaj   +1 more source

Adaptive Large Neighborhood Search for Vehicle Routing Problem with Cross-Docking

2020 IEEE Congress on Evolutionary Computation (CEC), 2020
Cross-docking is considered as a method to manage and control the inventory flow, which is essential in the context of supply chain management. This paper studies the integration of the vehicle routing problem with cross-docking, namely VRPCD which has been extensively studied due to its ability to reduce the overall costs occurring in a supply chain ...
Aldy Gunawan, Audrey Tedja Widjaja, Pieter Vansteenwegen, Vincent F. Yu   +3 more
openaire   +4 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

eVTOL Route Planning for Urban Low-Altitude Bus Services Considering Dynamic Passenger Load Variations and Battery Safety Constraints

Mathematics
Urban low-altitude bus operations require coordinated eVTOL route decisions under station time windows, dynamic passenger boarding and alighting, load-dependent energy consumption, opportunity charging, and battery safety requirements.
Guohua Wu, Wen Xie, Guangzhi Wang, Fangyu Hong, Fen Xing   +4 more
doaj   +1 more source