Results 51 to 60 of about 110,413 (286)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
, 2016 A greedy randomized adaptive search procedure (GRASP) is an itera- tive multistart metaheuristic for difficult combinatorial optimization problems. Each GRASP iteration consists of two phases: a construction phase, in which a feasible solution is ...
De Santis, M. +4 more
core +1 more source
An adaptive large neighborhood search heuristic for the Electric Vehicle Scheduling Problem [PDF]
Computers & Operations Research, 2016 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Wen, M. +4 more
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A template‐based adaptive large neighborhood search for the consistent vehicle routing problem [PDF]
Networks, 2013 Abstract–The importance of customer satisfaction was identified by many industries as a key factor of competitive advantage. So, for companies in the small package shipping industry, it can be reasonable to increase the service quality even at the expense of transportation cost to gain customer loyalty.
Kovacs, Attila A. +3 more
openaire +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Egyptian Informatics Journal, 2023 The multi-depot open vehicle routing problem (MDOVRP) differs from the classical VRP in that there is more than one depot and the vehicle does not need to return to a depot after serving the last customer. For solving this challenging problem, we propose
Wenhan Shao +4 more
doaj +1 more source
An Adaptive Iterated Local Search for the Mixed Capacitated General Routing Problem [PDF]
, 2016 We study the mixed capacitated general routing problem (MCGRP) in which a fleet of capacitated vehicles has to serve a set of requests by traversing a mixed weighted graph. The requests may be located on nodes, edges, and arcs.
DELL'AMICO, Mauro +3 more
core +3 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
An adaptive large neighborhood search for a full truckload routing problem in public works [PDF]
, 2015 International audienceThis paper presents a truck routing and scheduling problem faced by a public works company. Itconsists of optimizing the collection and delivery of materials between sites, using a heterogeneousfleet of vehicles.
Bostel, Nathalie +3 more
core +2 more sources