Results 71 to 80 of about 9,146 (257)

Improved Differential Evolution Algorithm to Solve the Advertising Method Selection Problem

Journal of Open Innovation: Technology, Market and Complexity, 2019
This article proposes a methodology to resolve the advertising method selection problem (AdSP). The use of different advertising methods for the same product can generate different responses in terms of the product’s sales volume. Companies selling
Malichan Thongkham, Tassin Srivarapongse
doaj   +1 more source

Reinforced Adaptive Large Neighborhood Search

, 2011
The Large Neighborhood Search metaheuristic for solving Constrained Optimization Problems has been proved to be effective on a wide range of problems. This Local Search heuristic has the particu- larity of using a complete search (such as Constraint Programming) to explore the large neighborhoods obtained by relaxing a fragment of the variables of the ...
Mairy, Jean-Baptiste, Deville, Yves, Van Hentenryck, Pascal, Eightth International Workshop on Local Search Techniques in Constraint Satisfaction (LSCS2011)   +3 more
openaire   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

A reinforcement learning model for dynamic distribution route optimization of agricultural products under replenishment demand

Alexandria Engineering Journal
Most existing logistics optimization models assume static demand or ignore transportation replenishment, which limits their applicability in dynamic agricultural environments.
Delong Zhu, Qianyang Liu, Dafa Zuo, Lujiang Yin, Baolin Li, Jiang Hu, Caozheng Yan, Bo He, Changchun Xue   +8 more
doaj   +1 more source

Formal and Informal Social Care in People With Rheumatic and Musculoskeletal Diseases: A Cross‐Sectional Multicenter Survey

Arthritis Care &Research, EarlyView.
Objective Rheumatic and musculoskeletal diseases (RMDs) are leading causes of physical disability, necessitating support with activities of daily living. This study describes social care received by patients with RMDs in two disparate regions of England: Salford (urban) and Norfolk (rural).
Mehreen Somro, Karen Durrant, William G. Dixon, John McBeth, Alex MacGregor, Max Yates, Jenny H. Humphreys   +6 more
wiley   +1 more source

Adaptive Simulated Annealing and Adaptive Large Neighborhood Search Algorithm for Solving Container Loading Problem: A Case Study [PDF]

International Journal of Industrial Engineering and Production Research
Adaptive Simulated Annealing (ASA) and Adaptive Large Neighborhood Search (ALNS) are two metaheuristic algorithms widely applied to solve discrete optimization problems. This study employs both algorithms to address the Container Loading Problem (CLP), a
Wahyu Kurniawan, Achmad Pratama Rifai, Nur Aini Masruroh   +2 more
doaj  

Static Pre-Scheduling for ICD Drayage Operations via Task Pooling and Enhanced Adaptive Large Neighborhood Search

Applied Sciences
Static pre-scheduling in inland container depot (ICD)-centered drayage must coordinate tractors, detachable load units, factory loading, and port deadlines before next-day execution. Conventional order-based routing is too rigid for mixed direct haulage,
Shucheng Fan, Shaochuan Fu
doaj   +1 more source

A hybrid adaptive large neighborhood search for time-dependent open electric vehicle routing problem with hybrid energy replenishment strategies. [PDF]

PLoS One, 2023
Fan L.
europepmc   +1 more source