Results 41 to 50 of about 836,230 (292)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

HAPPY: Hybrid Address-based Page Policy in DRAMs

open access: yes, 2015
Memory controllers have used static page closure policies to decide whether a row should be left open, open-page policy, or closed immediately, close-page policy, after the row has been accessed.
Garside, Jim   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The size of the immune repertoire of bacteria

open access: yes, 2019
Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against phage. In such species, individual bacteria maintain a "cassette" of viral DNA elements called spacers as a memory of past ...
Balasubramanian, Vijay   +3 more
core   +1 more source

Training of Working Memory Impacts Neural Processing of Vocal Pitch Regulation [PDF]

open access: yes, 2015
Working memory training can improve the performance of tasks that were not trained. Whether auditory-motor integration for voice control can benefit from working memory training, however, remains unclear.
Chen, Shaozhen   +7 more
core   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Interactions between the hippocampus, prefrontal cortex, and amygdala support complex learning and memory. [PDF]

open access: yes, 2019
One of the guiding principles of memory research in the preceding decades is multiple memory systems theory, which links specific task demands to specific anatomical structures and circuits that are thought to act orthogonally with respect to each other.
Fanselow, Michael S   +2 more
core  

The placement of the head that minimizes online memory: a complex systems approach

open access: yes, 2015
It is well known that the length of a syntactic dependency determines its online memory cost. Thus, the problem of the placement of a head and its dependents (complements or modifiers) that minimizes online memory is equivalent to the problem of the ...
Ferrer-i-Cancho, Ramon
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

An Adaptive Framework for Improving Quality of Service in Industrial Systems

open access: yesIEEE Access, 2015
Limited memory bandwidth is considered as the major bottleneck in multimedia cloud computing for more and more virtual machines (VMs) of multimedia processing requiring high memory bandwidth simultaneously.
Gangyong Jia   +4 more
doaj   +1 more source

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