Results 101 to 110 of about 2,461,215 (293)

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Combining Adaptive Hierarchical Depth Motion Maps With Skeletal Joints for Human Action Recognition

IEEE Access, 2019
This paper presents a new framework for human action recognition by fusing human motion with skeletal joints. First, adaptive hierarchical depth motion maps (AH-DMMs) are proposed to capture the shape and motion cues of action sequences. Specifically, AH-
Runwei Ding, Qinqin He, Hong Liu, Mengyuan Liu   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The Height-Adaptive Parameterized Step Length Measurement Method and Experiment Based on Motion Parameters

Sensors, 2018
In order to tackle the inaccurate step length measurement of people with different heights and in different motion states, a height-adaptive method of step length measurement based on motion parameters is proposed in this paper.
Yanshun Zhang, Yingyue Li, Chuang Peng, Dong Mou, Ming Li, Wei Wang   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Contrast-Independent Biologically Inspired Motion Detection [PDF]

, 2011
Babies B, Lindemann JP, Egelhaaf M, Möller R. Contrast-Independent Biologically Inspired Motion Detection. Sensors. 2011;11(12):3303-3326.Optic flow, i.e., retinal image movement resulting from ego-motion, is a crucial source of information used for ...
Lindemann, Jens Peter ; https://orcid.org/, Egelhaaf, Martin ; https://orcid.org/, Martin Egelhaaf, Jens Peter Lindemann, Ralf Möller, Birthe Babies, Möller, Ralf ; https://orcid.org/, Babies, Birthe   +7 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Motion Adaptive Pose Estimation from Compressed Videos

, 2022
Human pose estimation from videos has many real-world applications. Existing methods focus on applying models with a uniform computation profile on fully decoded frames, ignoring the freely-available motion signals and motion-compensation residuals from ...
Wang, Yao, Fan, Zhipeng, Liu, Jun
core   +1 more source