Results 91 to 100 of about 3,130,711 (363)

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Multiple sclerosis clinical decision support system based on projection to reference datasets

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022
Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch, Florent Chéneau, Françoise Simon, Guillaume Pasquier, Benoit Combès, Anne Kerbrat, Emmanuelle Le Page, Sophie Limou, Nicolas Vince, David‐Axel Laplaud, Franck Mars, Cédric Dumas, Gilles Edan, Pierre‐Antoine Gourraud   +13 more
wiley   +1 more source

ERIS: revitalising an adaptive optics instrument for the VLT [PDF]

Astronomical Telescopes + Instrumentation, 2018
ERIS is an instrument that will both extend and enhance the fundamental diffraction limited imaging and spectroscopy capability for the VLT. It will replace two instruments that are now being maintained beyond their operational lifetimes, combine their ...
Richard Davies, S. Esposito, H. Schmid, W. Taylor, G. Agapito, A. A. Berbel, A. Baruffolo, V. Biliotti, B. Biller, M. Black, A. Boehle, R. Briguglio, A. Buron, L. Carbonaro, Á. Cortés, G. Cresci, M. Deysenroth, A. D. Cianno, G. D. Rico, D. Doelman, M. Dolci, R. Dorn, F. Eisenhauer, D. Fantinel, D. Ferruzzi, H. Feuchtgruber, N. F. Schreiber, Xiaofeng Gao, H. Gemperlein, R. Genzel, E. George, S. Gillessen, C. Giordano, A. Glauser, A. Glindemann, P. Grani, M. Hartl, J. Heijmans, D. Henry, H. Huber, M. Kasper, C. Keller, M. Kenworthy, Jonas Kuehn, H. Kuntschner, J. Lightfood, D. Lunney, M. Macintosh, F. Mannucci, Stephen March, M. Neeser, P. Patapis, D. Pearson, M. Plattner, A. Puglisi, S. Quanz, C. Rau, A. Riccardi, B. Salasnich, J. Schubert, F. Snik, E. Sturm, A. Valentini, C. Waring, E. Wiezorrek, M. Xompero   +65 more
semanticscholar   +1 more source

Adaptive Optical Scanning Holography [PDF]

Scientific Reports, 2016
AbstractOptical Scanning Holography (OSH) is a powerful technique that employs a single-pixel sensor and a row-by-row scanning mechanism to capture the hologram of a wide-view, three-dimensional object. However, the time required to acquire a hologram with OSH is rather lengthy.
Ting-Chung Poon, Jung-Ping Liu, Peter Wai Ming Tsang   +2 more
openaire   +3 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers, Shanice Beerepoot, Ingeborg Krägeloh‐Mann, Saskia Elgün, Benjamin Bender, Marjo S. van der Knaap, Nicole I. Wolf, Samuel Groeschel   +7 more
wiley   +1 more source

ESL-YOLO: Small Object Detection with Effective Feature Enhancement and Spatial-Context-Guided Fusion Network for Remote Sensing

Remote Sensing
Improving the detection of small objects in remote sensing is essential for its extensive use in various applications. The diminutive size of these objects, coupled with the complex backgrounds in remote sensing images, complicates the detection process.
Xiangyue Zheng, Yijuan Qiu, Gang Zhang, Tao Lei, Ping Jiang   +4 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

SPDC-YOLO: An Efficient Small Target Detection Network Based on Improved YOLOv8 for Drone Aerial Image

Remote Sensing
Target detection in UAV images is of great significance in fields such as traffic safety, emergency rescue, and environmental monitoring. However, images captured by UAVs usually have multi-scale features, complex backgrounds, uneven illumination, and ...
Jingxin Bi, Keda Li, Xiangyue Zheng, Gang Zhang, Tao Lei   +4 more
doaj   +1 more source

Wavefront Restoration Technology of Dynamic Non-Uniform Intensity Distribution Based on Extreme Learning Machine

Sensors, 2021
Non-uniform intensity distribution of laser near-field beam results in the irregular shape of the spot in the wavefront sensor. The intensity of some sub-aperture spots may be too weak to be detected, and the accuracy of wavefront restoration is ...
Haiqi Lin, Xing He, Shuai Wang, Ping Yang   +3 more
doaj   +1 more source