Results 71 to 80 of about 1,509,291 (304)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Remote SensingImproving the detection of small objects in remote sensing is essential for its extensive use in various applications. The diminutive size of these objects, coupled with the complex backgrounds in remote sensing images, complicates the detection process.
Xiangyue Zheng +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
An experimental Rayleigh laser guide star ground layer adaptive optics system for the William Herschel telescope [PDF]
, 2005 The design of an experimental ground layer adaptive optics (GLAO) system that uses a low altitude Rayleigh laser guide star as a wavefront reference source is presented.
Morris, T J, Morris, T. J.
core
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingInfrared small target detection is significantly challenged by residual high-intensity background edges and a low signal-to-noise ratio. These issues hinder accurate target differentiation from the background and heighten the risk of false alarms.
Xuying Hao +6 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Adaptive optics point spread function reconstruction directly from target data
, 2016 Paper AOT2C.1, 3 S.Reconstruction of point spread function (PSF) using information from the wavefront sensor is a classic problem in adaptive optics. Although the theory and methods for this task have been in use for the last twenty years, implementation
Szymon Gladysz, Gladysz, Szymon
core +1 more source
, 2022 We discuss the capability of adaptive optics to increase the performance of laser systems operating in atmospheric turbulence. Our approach is based on the Zernike filter functions, Taylor’s frozen flow hypothesis and bandwidth limitations of a realistic
Gladysz, Szymon, Toselli, Italo
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
The numerical simulation tool for the MAORY multiconjugate adaptive optics system [PDF]
, 2016 The Multiconjugate Adaptive Optics RelaY (MAORY) is and Adaptive Optics module to be mounted on the ESO European-Extremely Large Telescope (E-ELT).
XOMPERO, MARCO +33 more
core +1 more source