Results 101 to 110 of about 3,130,711 (363)

Functional retinal imaging using adaptive optics swept-source OCT at 1.6MHz

bioRxiv, 2018
Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging.
Mehdi Azimipour, J. Migacz, R. Zawadzki, J. Werner, R. Jonnal   +4 more
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Active PSF Shaping and Adaptive Optics Enable Volumetric Localization Microscopy through Brain Sections

Nature Methods, 2018
Application of single-molecule switching nanoscopy (SMSN) beyond the coverslip surface poses substantial challenges due to sample-induced aberrations that distort and blur single-molecule emission patterns.
Michael J. Mlodzianoski, Paul J. Cheng-Hathaway, S. Bemiller, Tyler J. McCray, Sheng Liu, David A. Miller, B. Lamb, G. Landreth, Fang Huang   +8 more
semanticscholar   +1 more source

The ERIS adaptive optics system [PDF]

SPIE Proceedings, 2016
ERIS is the new AO instrument for VLT-UT4 led by a Consortium of Max-Planck Institut fuer Extraterrestrische Physik, UK-ATC, ETH-Zurich, ESO and INAF. The ERIS AO system provides NGS mode to deliver high contrast correction and LGS mode to extend high Strehl performance to large sky coverage.
RICCARDI, Armando, ESPOSITO, Simone, AGAPITO, GUIDO, Antichi, J., BILIOTTI, Valdemaro, Blain, C., BRIGUGLIO PELLEGRINO, RUNA ANTONIO, BUSONI, LORENZO, CARBONARO, LUCA, DI RICO, Gianluca, Giordano, C., PINNA, Enrico, PUGLISI, Alfio Timothy, Spanò, P., XOMPERO, MARCO, BARUFFOLO, Andrea, Kasper, M., Egner, S., Suàrez Valles, M., Soenke, C., Downing, M., Reyes, J.   +21 more
openaire   +4 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

A Reparameterization Feature Redundancy Extract Network for Unmanned Aerial Vehicles Detection

Remote Sensing
In unmanned aerial vehicles (UAVs) detection, challenges such as occlusion, complex backgrounds, motion blur, and inference time often lead to false detections and missed detections.
Shijie Zhang, Xu Yang, Chao Geng, Xinyang Li   +3 more
doaj   +1 more source

Adaptive SMF Coupling Based on Precise-Delayed SPGD Algorithm and Its Application in Free Space Optical Communication

IEEE Photonics Journal, 2018
The adaptive coupling of laser beam from space into single-mode fiber (SMF) plays an important role in the fiber-based free space optical communication technology.
Guan Huang, Chao Geng, Feng Li, Yan Yang, Xinyang Li   +4 more
doaj   +1 more source

Trans-retinal cellular imaging with multimodal adaptive optics

Biomedical Optics Express, 2018
Adaptive optics (AO), when coupled to different imaging modalities, has enabled resolution of various cell types across the entire retinal depth in the living human eye.
Zhuolin Liu, Johnny Tam, O. Saeedi, D. Hammer   +3 more
semanticscholar   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

Co-Phase Error Detection for Segmented Mirrors Based on Far-Field Information and Transfer Learning

Photonics
The resolution of a telescope is closely related to its aperture size; however, the aperture of a single primary mirror telescope cannot be indefinitely enlarged due to design and manufacturing constraints.
Kunkun Cheng, Shengqian Wang, Xuesheng Liu, Yuandong Cheng   +3 more
doaj   +1 more source