Results 61 to 70 of about 16,964 (253)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

A Reparameterization Feature Redundancy Extract Network for Unmanned Aerial Vehicles Detection

open access: yesRemote Sensing
In unmanned aerial vehicles (UAVs) detection, challenges such as occlusion, complex backgrounds, motion blur, and inference time often lead to false detections and missed detections.
Shijie Zhang   +3 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Infrared Tall Patch-Matrix Model for Single-Frame Low-Contrast Small Target Detection

open access: yesApplied Sciences
Infrared small target detection (IRSTD) task is vital in practical applications. It is still a challenge when the target size is very small and the local signal-to-noise ratio is particularly low.
Yujia Liu, Wei Tang, Xuying Hao, Tao Lei
doaj   +1 more source

Adaptive SMF Coupling Based on Precise-Delayed SPGD Algorithm and Its Application in Free Space Optical Communication

open access: yesIEEE Photonics Journal, 2018
The adaptive coupling of laser beam from space into single-mode fiber (SMF) plays an important role in the fiber-based free space optical communication technology.
Guan Huang   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Quantitative assessment of parameter requirements in a division of focal plane polarimeter

open access: yesScientific Reports
The division of focal plane polarimeter (DoFP) is a widely utilized instrument for target detection and recognition, owing to its excellent real-time performance and compact configuration.
Bowen Lian   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Control Bandwidth Promotion of Adaptive Fiber-Optics Collimator and Its Application in Coherent Beam Combination

open access: yesIEEE Photonics Journal, 2018
Adaptive fiber-optics collimator (AFOC) plays an important role in the coherent beam combining (CBC) systems. To improve the control bandwidth, the frequency characteristics of AFOC are measured, and an accurate transfer function model is established ...
Guan Huang   +4 more
doaj   +1 more source

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