Results 81 to 90 of about 142,915 (284)

Control Bandwidth Promotion of Adaptive Fiber-Optics Collimator and Its Application in Coherent Beam Combination

open access: yesIEEE Photonics Journal, 2018
Adaptive fiber-optics collimator (AFOC) plays an important role in the coherent beam combining (CBC) systems. To improve the control bandwidth, the frequency characteristics of AFOC are measured, and an accurate transfer function model is established ...
Guan Huang   +4 more
doaj   +1 more source

Adaptive Optics Correction of the Wavefront Distortions Induced by Segments Misalignment in Extremely Large Telescope [PDF]

open access: yes, 2006
The capability of the adaptive optics to correct for the segmentation error is analyzed in terms of the residual wavefront RMS and the power spectral density of the phase.
Verinaud, Christophe, Yaitskova, Natalia
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Adaptive Optics: introduction to the feature issue [PDF]

open access: yes, 2010
This Applied Optics feature issue is a companion to the Journal of the Optical Society of America A feature issue on the same topic. The feature highlights the expansion of adaptive optics to different applications as well as its development to routine ...
Christou, Julian   +3 more
core  

Ground-Based Coronagraphy with High Order Adaptive Optics [PDF]

open access: yes, 2001
We summarize the theory of coronagraphic optics, and identify a dimensionless fine-tuning parameter, F, which we use to describe the Lyot stop size in the natural units of the coronagraphic optical train and the observing wavelength.
Anand Sivaramakrishnan   +11 more
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Integrated Laboratory Demonstrations of Multi-Object Adaptive Optics on a Simulated 10-Meter Telescope at Visible Wavelengths [PDF]

open access: yes, 2009
One important frontier for astronomical adaptive optics (AO) involves methods such as Multi-Object AO and Multi-Conjugate AO that have the potential to give a significantly larger field of view than conventional AO techniques.
Ammons, S. Mark   +6 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

The Robo-AO-2 facility for rapid visible/near-infrared AO imaging and the demonstration of hybrid techniques [PDF]

open access: yes, 2018
We are building a next-generation laser adaptive optics system, Robo-AO-2, for the UH 2.2-m telescope that will deliver robotic, diffraction-limited observations at visible and near-infrared wavelengths in unprecedented numbers.
Baranec, Christoph   +25 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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