Results 41 to 50 of about 15,284 (261)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

All-optical recording and stimulation of retinal neurons in vivo in retinal degeneration mice. [PDF]

open access: yesPLoS ONE, 2018
Here we demonstrate the application of a method that could accelerate the development of novel therapies by allowing direct and repeatable visualization of cellular function in the living eye, to study loss of vision in animal models of retinal disease ...
Soon Keen Cheong   +3 more
doaj   +1 more source

A Local Threshold Checkerboard Algorithm for Adaptive Optics System With a Plenoptic Sensor

open access: yesIEEE Photonics Journal, 2022
Adaptive optics systems will encounter challenges under strong atmospheric turbulence conditions. Recently, a modified approach based on plenoptic sensor has attracted considerable attention.
Zhichong Wang   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Astroclimatic statistics at the Sayan Solar Observatory

open access: yesSolar-Terrestrial Physics, 2020
The paper analyzes meteorological and optical characteristics of the atmosphere at the Sayan Solar Observatory (SSO) and the future 3 m Large Solar Telescope (LST-3).
Shikhovtsev A.Yu.   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Wavefront Recovery for Multiple Sun Regions in Solar SCAO Scenarios with Deep Learning Techniques

open access: yesMathematics, 2023
The main objective of an Adaptive Optics (AO) system is to correct the aberrations produced in the received wavefronts, caused by atmospheric turbulence.
Sergio Luis Suárez Gómez   +6 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Optical power allocation for adaptive transmissions in wavelength-division multiplexing free space optical networks

open access: yesDigital Communications and Networks, 2015
Attracting increasing attention in recent years, the Free Space Optics (FSO) technology has been recognized as a cost-effective wireless access technology for multi-Gigabit rate wireless networks.
Hui Zhou, Shiwen Mao, Prathima Agrawal
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

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