Results 61 to 70 of about 15,284 (261)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Coherent Adaptive Optical System
Conference on Lasers and Electro-Optics, 2017 An adaptive optical system in which coherent images are processed to determine wavefront error and the error is corrected by applying the inverse to a deformable mirror is discussed.
J. Marron, K. Heideman
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina. [PDF]
Biomed Opt Express, 2022 Liu Z +4 more
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Research Progress of Deformable Mirror and Its Control Algorithm
Guangtongxin yanjiu【Objective】Deformable Mirror(DM) is a key device in adaptive optics system for wavefront correction, and its performance directly determines the wavefront correction capability of the system.
LIANG Jingyuan +7 more
doaj
PhotonicsIn this paper, we introduce atmospheric adaptive optics (AO) system architectures that utilize scintillation-resistant wavefront sensors based on iterative phase retrieval (IPR) techniques (described in detail in Part I) for closed-loop mitigation of ...
Mikhail A. Vorontsov, Ernst Polnau
doaj +1 more source
Vision with spatial light modulator simulating multifocal contact lenses in an adaptive optics system. [PDF]
Biomed Opt Express, 2021 Vedhakrishnan S +3 more
europepmc +1 more source