Results 81 to 90 of about 18,252,740 (310)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Adaptive optics for the CHARA array [PDF]

, 2016
The CHARA Array is a six telescope optical/IR interferometer run by the Center for High Angular Resolution Astronomy of Georgia State University and is located at Mount Wilson Observatory just to the north of Los Angeles California.
Ridgway, Stephen T, Sturmann, Laszlo, Sturmann, J, Turner, Nils, Che, X, Tuthill, P G, ten Brummelaar, Theo, Monnier, J. D, McAlister, H, Ireland, Michael, Ireland, M. J   +10 more
core   +1 more source

Adaptive optics system for the observation of terrestrial point-like sources: Results and problems

, 2022
Paper 78280KThe development of a system intended as a demonstrator for improving the tracking of distant point-like sources through the correction of the atmospheric optical distortions is here reported.
Marchi, G.
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Simulation of Coherent Beam Propagation in Laboratory and Numerical Experiments: A Comparison of Results

Photonics
This paper presents the results of processing and systematizing data from laboratory and numerical experiments to correct the distortions of laser radiation propagating through a randomly inhomogeneous medium.
Feodor Kanev, Alexey Rukosuev, Ilya Galaktionov, Julia Sheldakova, Igor Veretekhin   +4 more
doaj   +1 more source

Adaptive optics for laser space debris removal [PDF]

, 2016
Space debris in low Earth orbit below 1500km is becoming an increasing threat to satellites and spacecrafts. Radar and laser tracking are currently used to monitor the orbits of thousands of space debris and active satellites are able to use this ...
Rigaut, Francois, Conan, Rodolphe, d'Orgeville, Celine, Ritchie, Ian, Smith, C, Dawson, Murray, Bennet, Francis, Paulin, Nicolas, Uhlendorf, Kristina, Price, Ian   +9 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

MAVIS: The adaptive optics module feasibility study [PDF]

, 2020
The Adaptive Optics Module of MAVIS is a self-contained MCAO module, which delivers a corrected FoV to the postfocal scientific instruments, in the visible.
Fusco T., Brodrick D., RADHAKRISHNAN SANTHAKUMARI, KALYAN KUMAR, Aliverti, Matteo, Gausachs G., VIOTTO, VALENTINA, PINNA, Enrico, ESPOSITO, Simone, Vassallo, Daniele, ARCIDIACONO, CARMELO, AGAPITO, GUIDO, Beltramo-Martin O., GREGGIO, DAVIDE, Gratadour D., MAGRIN, DEMETRIO, Ströbele S., BONAGLIA, MARCO, CAROLO, ELENA, FARINATO, JACOPO, Vaccarella A., Haguenauer P., Rigaut F., BERGOMI, Maria, CHINELLATO, SIMONETTA, Cranney J., Neichel B., PLANTET, CEDRIC ANTOINE ADRIEN GABRIEL, BUSONI, LORENZO, MARAFATTO, Luca, RAGAZZONI, Roberto   +29 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Experimental Demonstration of Sequential Operation Approach for a Three-Sided Pyramid Wavefront Sensor

IEEE Photonics Journal, 2016
We describe a sequential operation approach for a three-sided pyramid wavefront sensor (PWFS) based on a micromirror array with hexagonal geometry. The geometrical optics analysis and numerical simulations show that a linear relationship exists between ...
Lu Chen, Jianli Wang, Kainan Yao, Xinyue Liu, Xudong Lin, Liang Wang, Minghao Wang   +6 more
doaj   +1 more source