Results 81 to 90 of about 21,086 (310)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Experimental Demonstration of Sequential Operation Approach for a Three-Sided Pyramid Wavefront Sensor

IEEE Photonics Journal, 2016
We describe a sequential operation approach for a three-sided pyramid wavefront sensor (PWFS) based on a micromirror array with hexagonal geometry. The geometrical optics analysis and numerical simulations show that a linear relationship exists between ...
Lu Chen, Jianli Wang, Kainan Yao, Xinyue Liu, Xudong Lin, Liang Wang, Minghao Wang   +6 more
doaj   +1 more source

Coherent Adaptive Optical System

Conference on Lasers and Electro-Optics, 2017
An adaptive optical system in which coherent images are processed to determine wavefront error and the error is corrected by applying the inverse to a deformable mirror is discussed.
J. Marron, K. Heideman
openaire   +2 more sources

Micro-Deformable Mirror: a low cost technology for cryogenic active and adaptive optics [PDF]

, 1999
Electrostatically operated bi-directional deflecting silicon membranes can be created using bulk micromachining techniques. The 19-channel Micro-Deformable Mirror, potential candidate for space Active and Adaptive Optics, was built by OKO Technologies ...
Bonicel, Sebastien Louis
core  

MAORY: adaptive optics module for the E-ELT [PDF]

, 2016
MAORY is one of the four instruments for the E-ELT approved for construction. It is an adaptive optics module offering two compensation modes: multi-conjugate and single-conjugate adaptive optics. The project has recently entered its phase B.
FANTINEL, Daniela, FIORENTINO, Giuliana, FOPPIANI, ITALO, Magnard, Y., Oberti, S., Felini, C., Roussel, F., MANNUCCI, FILIPPO, Sztefek, M. -H., BRIGUGLIO PELLEGRINO, RUNA ANTONIO, Brissaud, O., Roux, A., ESPOSITO, Simone, DIOLAITI, EMILIANO, Moulin, T., PUGLISI, Alfio Timothy, Stadler, E., Lafrasse, S., Michaud, L., DE PASCALE, Marco, Hénault, F., Le Louarn, M., DI RICO, Gianluca, FONTANA, Adriano, ABICCA, Renata, LOMBINI, MATTEO, RIVA, Marco, GIRO, Enrico, Rabou, P., Fini, L., FERRUZZI, Debora, Rochat, S., La Penna, P., Carlotti, A., MORGANTE, GIANLUCA, RICCIARDI, SARA, Jocou, L., Mapelli, M., Zerbi, F. M., Lauria, M., Marchetti, E., Delboulbé, A., XOMPERO, MARCO, BILIOTTI, Valdemaro, GHIGO, Mauro, Maurel, D., Cosentino, G., le Coarer, E., SCHREIBER, LAURA, ARCIDIACONO, CARMELO, Kerber, F., Gluck, L., Correia, J. -J., Ramsay, S., Giordano, C., SPAVONE, MARILENA, AGAPITO, GUIDO, MAIORANO, Elisabetta, Vérinaud, C., CASCONE, Enrico, PARESCHI, Giovanni, BONAGLIA, MARCO, DE CAPRIO, VINCENZO, SALASNICH, Bernardo, De Rosa, A., Ventura, N., BREGOLI, Giovanni, CORTECCHIA, Fausto, CILIEGI, Paolo, BARUFFOLO, Andrea, CARBONARO, LUCA, BELLAZZINI, Michele, BUSONI, LORENZO, RICCARDI, Armando, Feautrier, P., Patti, Mauro, SARACCO, Paolo, DEL VECCHIO, Ciro, RAGAZZONI, Roberto   +78 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A Comprehensive Review of Machine Learning Applications in Laser Optics

IEEE Photonics Journal
Machine learning (ML) has emerged as a transformative tool in laser-based optics, driving advancements in both fundamental research and industrial applications.
Saadman Yasar, Murat Yuksel
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Real-time real-sky dual-conjugate adaptive optics experiment

, 2006
The current status of a real-time real-sky dual-conjugate adaptive optics experiment is presented. This experiment is a follow-up on a lab experiment at Lund Observatory that demonstrated dual-conjugate adaptive optics on a static atmosphere.
Per Knutsson, Knutsson, Per, Owner-Petersen, Mette, Mette Owner-Petersen   +3 more
core   +1 more source