Results 61 to 70 of about 366,081 (322)

Toward robust adaptive radiation therapy strategies [PDF]

Medical Physics, 2017
The authors propose robust adaptive strategies based on stochastic minimax optimization for a series of simulated treatments on a one-dimensional patient phantom. The plan applied during the first fractions should be able to handle anticipated systematic and random errors.
Böck, Michelle, Forsgren, Anders, Eriksson, Kjell, Hårdemark, Björn   +3 more
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A Study to Assess the Dosimetric Impact of the Anatomical Changes Occurring in the Parotid Glands and Tumour Volume during Intensity Modulated Radiotherapy using Simultaneous Integrated Boost (IMRT‐SIB) in Head and Neck Squamous Cell Cancers

Cancer Medicine, 2021
Background Anatomical variations in head and neck cancer during IMRT leads to volume shrinkage, results in dosimetric variations in tumour and normal tissue including parotid glands, with a risk of radiation toxicities.
Arunima Ghosh, Seema Gupta, Danial Johny, Vivek Vidyadhar Bhosale, Mahendra Pal Singh Negi   +4 more
doaj   +1 more source

Induction of adaptive response in utero by ionizing radiation: A radiation quality dependent phenomenon [PDF]

, 2022
BING WANG, Kaoru Tanaka, Kouichi Maruyama, YASUHARA NINOMIYA, Takanori Katsube, Mitsuru Nenoi   +5 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The More You Search, the More You Find: A New Mediterranean Endemism of the Genus Ocenebra Gray, 1847 (Mollusca: Gastropoda: Muricidae) from a Submarine Cave of the Messina Strait Area (Italy)

Journal of Marine Science and Engineering, 2020
Three hundred years of study on the Mediterranean molluscan fauna led the scientific community to consider it as the best ever known. However, the rate at which new taxa are discovered and described every year is still remarkably high, even in key ...
Fabio Crocetta, Roland Houart, Giuseppe Bonomolo   +2 more
doaj   +1 more source

A new blind adaptive antenna array for GNSS interference cancellation [PDF]

, 2005
This paper introduces a new blind adaptive antenna array as a possible solution to the interference cancellation problem. This new technique is compared to three classical ones over two different sensor radiation patterns.
Carrie, Guillaume, Deloues, Thierry, Pietin, David, Renard, Alain, Vincent, François   +4 more
core  

The Birth of a Galaxy. II. The Role of Radiation Pressure

, 2012
Massive stars provide feedback that shapes the interstellar medium of galaxies at all redshifts and their resulting stellar populations. Here we present three adaptive mesh refinement radiation hydrodynamics simulations that illustrate the impact of ...
Abel, Abel, Abel, Abel, Aguirre, Aguirre, Aguirre, Anninos, Bally, Benson, Bergin, Bertschinger, Bouwens, Bouwens, Bovill, Britton D. Smith, Bromm, Brook, Bryan, Caffau, Calzetti, Cen, Chabrier, Couchman, Dalla Vecchia, Danovich, Davies, Dekel, Draine, Draine, Eddington, Efstathiou, Fan, Ferrara, Ferrarese, Finkelstein, Finlator, Franco, Frebel, Gebhardt, Glover, Gnedin, Gnedin, Gnedin, Governato, Governato, Grebel, Greif, Greif, Greif, Grevesse, Guedes, Guo, Górski, Haehnelt, Heger, Heger, Henney, Hopkins, John H. Wise, Jubelgas, Karim, Katz, Khochfar, Kirby, Kitayama, Komatsu, Kotarba, Krumholz, Krumholz, Lehnert, Li, Machacek, Madau, Matthew J. Turk, Matzner, Matzner, McKee, McLure, McLure, Michael L. Norman, Monelli, Murray, Murray, Nomoto, Norman, O'Shea, O'Shea, Omukai, Oppenheimer, Ouchi, Safranek-Shrader, Sales, Sanders, Schaerer, Schaerer, Schaerer, Semenov, Shapiro, Shu, Smith, Socrates, Springel, Stark, Tegmark, Thacker, Thompson, Tolstoy, Tolstoy, Tom Abel, Toro, Tremaine, Trenti, Truelove, Turk, Wang, Wechsler, Whalen, Whalen, Wise, Wise, Wise, Wise, Wise, Wise, Wise, Woodward, Woosley, Yorke   +128 more
core   +1 more source